Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Nat Struct Mol Biol. 2018 Jan;25(1):13-20. doi: 10.1038/s41594-017-0010-8. Epub 2018 Jan 8.
Zika virus (ZIKV) is an enveloped, icosahedral flavivirus that has structural and functional similarities to other human flavivirus pathogens such as dengue (DENV), West Nile (WNV) and Japanese encephalitis (JEV) viruses. ZIKV infections have been linked to fetal microcephaly and the paralytic Guillain-Barré syndrome. This review provides a comparative structural analysis of the assembly, maturation and host-cell entry of ZIKV with other flaviviruses, especially DENV. We also discuss the mechanisms of neutralization by antibodies.
Zika 病毒（ZIKV）是一种包膜、二十面体的黄病毒，与其他人类黄病毒病原体（如登革热病毒（DENV）、西尼罗河病毒（WNV）和日本脑炎病毒（JEV））具有结构和功能上的相似性。ZIKV 感染与胎儿小头畸形和麻痹性格林-巴利综合征有关。本综述对 ZIKV 与其他黄病毒（特别是 DENV）的组装、成熟和宿主细胞进入进行了比较结构分析。我们还讨论了抗体中和的机制。
