2017年骨关节炎：膝关节骨关节炎管理的最新进展 - Suppr

Osteoarthritis in 2017: Latest advances in the management of knee OA.

作者信息

McAlindon Timothy E, Bannuru Raveendhara R

机构信息

Center for Treatment Comparison and Integrative Analysis (CTCIA), Division of Rheumatology, Tufts Medical Center, 800 Washington Street, Boston, Massachusetts 02111, USA.

出版信息

Nat Rev Rheumatol. 2018 Feb;14(2):73-74. doi: 10.1038/nrrheum.2017.219. Epub 2018 Jan 11.

DOI:10.1038/nrrheum.2017.219

PMID:29323340

Abstract

摘要

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Osteoarthritis in 2017: Latest advances in the management of knee OA.2017年骨关节炎：膝关节骨关节炎管理的最新进展

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Pharmacodynamics, efficacy, safety and administration of intra-articular therapies for knee osteoarthritis.关节内注射治疗膝骨关节炎的药效学、疗效、安全性和给药方法。

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Efficacy of intraarticular hyaluronan in the treatment of knee osteoarthritis: comment on the article by Brandt et al.关节内注射透明质酸治疗膝骨关节炎的疗效：对布兰特等人文章的评论

Arthritis Rheum. 2001 Jun;44(6):1471-6. doi: 10.1002/1529-0131(200106)44:6<1471::AID-ART245>3.0.CO;2-H.

Osteoarthritis: A single injection of anakinra for treating knee OA?骨关节炎：单次注射阿那白滞素治疗膝骨关节炎？

Nat Rev Rheumatol. 2009 Jul;5(7):363-4. doi: 10.1038/nrrheum.2009.121.

Lorecivivint, an intra-articular potential disease-modifying osteoarthritis drug.洛塞昔芬，一种关节内潜在的治疗骨关节炎的药物。

Expert Opin Investig Drugs. 2020 Dec;29(12):1339-1346. doi: 10.1080/13543784.2020.1842357. Epub 2020 Nov 8.

Evidence-based guidelines for intra-articular injection in knee osteoarthritis: Formulating and evaluating research questions.膝关节骨关节炎关节内注射的循证指南：提出与评估研究问题

Int J Rheum Dis. 2018 Aug;21(8):1533-1542. doi: 10.1111/1756-185X.13367.

Treatment of intraarticular osteoarthritis of the knee with hylan G-F 20: comment on the article by Brandt et al.用透明质酸钠（Hylan G-F 20）治疗膝关节内骨关节炎：对布兰特等人文章的评论

Arthritis Rheum. 2001 Jun;44(6):1470-1; author reply 1473-6. doi: 10.1002/1529-0131(200106)44:6<1470::AID-ART244>3.0.CO;2-N.

Bilateral symmetric inflammatory reaction to hylan G-F 20 injection.对透明质烷G-F 20注射的双侧对称炎症反应。

Arthritis Rheum. 2001 Apr;44(4):978-9. doi: 10.1002/1529-0131(200104)44:4<978::AID-ANR156>3.0.CO;2-N.

HYADD 4 versus methylprednisolone acetate in symptomatic knee osteoarthritis: a single-centre single blind prospective randomised controlled clinical study with 1-year follow-up.症状性膝关节骨关节炎中透明质酸衍生物4与醋酸甲基泼尼松龙的比较：一项为期1年随访的单中心单盲前瞻性随机对照临床研究

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Comparative evaluation of therapeutic efficacy of intra-articular oxaceprol with conventional modalities in osteoarthritis animal model.比较关节内注射氧嗪酸与常规疗法治疗骨关节炎动物模型的疗效。

Clin Rheumatol. 2018 Aug;37(8):2195-2201. doi: 10.1007/s10067-018-4087-1. Epub 2018 Apr 10.

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Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1.人参三醇通过靶向UFL1发挥抗衰老作用，并减轻骨关节炎和软骨修复纤维化。

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Osteopontin (OPN) alleviates the progression of osteoarthritis by promoting the anabolism of chondrocytes.骨桥蛋白（OPN）通过促进软骨细胞的合成代谢来缓解骨关节炎的进展。

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Recent Advances in Small Molecule Inhibitors for the Treatment of Osteoarthritis.用于治疗骨关节炎的小分子抑制剂的最新进展

J Clin Med. 2023 Mar 2;12(5):1986. doi: 10.3390/jcm12051986.

Randomized controlled trial of aquatic exercise for treatment of knee osteoarthritis in elderly people.老年人膝关节骨关节炎水疗运动治疗的随机对照试验

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Root Extract Mediates Anti-Inflammatory Effects in Osteoarthritis Synoviocytes through CB2 Activation.根提取物通过激活CB2介导骨关节炎滑膜细胞的抗炎作用。

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Exercise to Mend Aged-tissue Crosstalk in Bone Targeting Osteoporosis & Osteoarthritis.运动修复靶向骨质疏松症和骨关节炎的组织老化对话。

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lncRNA FER1L4 is dysregulated in osteoarthritis and regulates IL-6 expression in human chondrocyte cells.长链非编码 RNA FER1L4 在骨关节炎中失调，并调节人软骨细胞中的 IL-6 表达。

Sci Rep. 2021 Jun 22;11(1):13032. doi: 10.1038/s41598-021-92474-8.

Antiarthritic Effects of a Root Extract from DC: Novel Insights into the Molecular Mechanisms and Possible Bioactive Phytochemicals.抗关节炎作用的根提取物从 DC：分子机制的新见解和可能的生物活性植物化学物质。

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Risk factors for joint replacement in knee osteoarthritis; a 15-year follow-up study.膝关节骨关节炎行关节置换的危险因素；一项15年随访研究。

BMC Musculoskelet Disord. 2017 Dec 4;18(1):510. doi: 10.1186/s12891-017-1871-z.

Brief Report: A Phase IIb Trial of a Novel Extended-Release Microsphere Formulation of Triamcinolone Acetonide for Intraarticular Injection in Knee Osteoarthritis.简要报告：曲安奈德新型缓释微球关节内注射治疗膝骨关节炎的 IIb 期临床试验。

Arthritis Rheumatol. 2018 Feb;70(2):204-211. doi: 10.1002/art.40364. Epub 2017 Dec 20.

A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee.一种 Wnt 通路的小分子抑制剂（SM04690）作为一种潜在的疾病修饰剂用于治疗膝关节骨关节炎。

Osteoarthritis Cartilage. 2018 Jan;26(1):18-27. doi: 10.1016/j.joca.2017.08.015. Epub 2017 Sep 6.

A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study.一种新型 Wnt 通路抑制剂 SM04690 治疗膝关节中重度骨关节炎的 24 周随机对照 1 期研究结果。

Osteoarthritis Cartilage. 2017 Oct;25(10):1598-1606. doi: 10.1016/j.joca.2017.07.006. Epub 2017 Jul 13.

Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients With Knee Osteoarthritis: A Randomized Clinical Trial.关节内注射曲安奈德与生理盐水对膝骨关节炎患者膝关节软骨体积和疼痛的影响：一项随机临床试验

JAMA. 2017 May 16;317(19):1967-1975. doi: 10.1001/jama.2017.5283.

Effectiveness and Implications of Alternative Placebo Treatments: A Systematic Review and Network Meta-analysis of Osteoarthritis Trials.替代安慰剂治疗的效果和意义：骨关节炎试验的系统评价和网络荟萃分析。

Ann Intern Med. 2015 Sep 1;163(5):365-72. doi: 10.7326/M15-0623.

An intra-articular, extended-release formulation of triamcinolone acetonide prolongs and amplifies analgesic effect in patients with osteoarthritis of the knee: a randomized clinical trial.关节内注射曲安奈德长效制剂可延长并增强膝关节骨关节炎患者的镇痛效果：一项随机临床试验。

J Bone Joint Surg Am. 2015 Jun 3;97(11):877-88. doi: 10.2106/JBJS.N.00918.

OARSI guidelines for the non-surgical management of knee osteoarthritis.美国骨与软组织放射学会膝关节骨关节炎非手术治疗指南

Osteoarthritis Cartilage. 2014 Mar;22(3):363-88. doi: 10.1016/j.joca.2014.01.003. Epub 2014 Jan 24.

Rate of cartilage loss at two years predicts subsequent total knee arthroplasty: a prospective study.两年时的软骨流失率可预测后续全膝关节置换术：一项前瞻性研究。

Ann Rheum Dis. 2004 Sep;63(9):1124-7. doi: 10.1136/ard.2004.021253. Epub 2004 Apr 28.

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Osteoarthritis in 2017: Latest advances in the management of knee OA.

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