UMR-1238, INSERM, Equipe 1, Faculté de Médecine de l'Université de Nantes, Nantes, France.
Department of Basic Studies, Faculty of Odontology, University of Antioquia, Medellin, Colombia.
J Cell Physiol. 2018 Aug;233(8):5696-5715. doi: 10.1002/jcp.26465. Epub 2018 Mar 7.
Bisphosphonates are considered the most effective drugs for controlling adult and pediatric osteolytic diseases. Although they have been used successfully for many years, several side effects, such as osteonecrosis of the jaw, delayed dental eruption, atypical femoral fracture, and alterations to the bone growth system, have been described. After an overview of nitrogenous bisphosphonate, the purpose of this article is to describe their mechanisms of action and current applications, review the preclinical and clinical evidence of their side effects in the skeleton ("what we know"), and describe current recommendations for preventing and managing these effects ("what we can do"). Finally, promising future directions on how to limit the occurrence of these side effects will be presented.
双膦酸盐被认为是控制成人和儿科溶骨性疾病最有效的药物。尽管它们已经成功使用了多年，但仍有一些副作用，如颌骨坏死、牙齿延迟萌出、非典型股骨骨折和骨骼生长系统的改变。在概述了氮双膦酸盐之后，本文的目的是描述它们的作用机制和当前的应用，回顾它们在骨骼中的副作用的临床前和临床证据（“我们知道什么”），并描述预防和管理这些副作用的当前建议（“我们能做什么”）。最后，将介绍如何限制这些副作用发生的有前途的未来方向。
