School of Engineering Medicine, Beihang University, Beijing 100191, China.
School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China.
Int J Mol Sci. 2023 Sep 20;24(18):14326. doi: 10.3390/ijms241814326.
Bones are constantly exposed to mechanical forces from both muscles and Earth's gravity to maintain bone homeostasis by stimulating bone formation. Mechanotransduction transforms external mechanical signals such as force, fluid flow shear, and gravity into intracellular responses to achieve force adaptation. However, the underlying molecular mechanisms on the conversion from mechanical signals into bone formation has not been completely defined yet. In the present review, we provide a comprehensive and systematic description of the mechanotransduction signaling pathways induced by mechanical stimuli during osteogenesis and address the different layers of interconnections between different signaling pathways. Further exploration of mechanotransduction would benefit patients with osteoporosis, including the aging population and postmenopausal women.
骨骼不断受到肌肉和地球引力产生的机械力的作用，通过刺激骨形成来维持骨稳态。力学转导将力、流体剪切力和重力等外部机械信号转化为细胞内反应，以实现力适应。然而，机械信号转化为骨形成的潜在分子机制尚未完全确定。在本综述中，我们全面系统地描述了成骨过程中机械刺激诱导的力学转导信号通路，并探讨了不同信号通路之间的不同层次的相互联系。对力学转导的进一步探索将使骨质疏松症患者受益，包括老年人口和绝经后妇女。
