产乳酸沙门氏菌：一种源自宿主的发酵产物为病原体生长提供燃料。
LACTATEing Salmonella: A Host-Derived Fermentation Product Fuels Pathogen Growth.
机构信息
Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine, LMU Munich, Pettenkoferstr. 9a, 80336 Munich, Germany; German Center for Infection Research (DZIF), Partner Site LMU Munich, Munich, Germany.
Munich Center for Integrated Protein Science (CIPSM) at the Department of Microbiology, LMU Munich, 82152 Martinsried, Germany.
出版信息
Cell Host Microbe. 2018 Jan 10;23(1):3-4. doi: 10.1016/j.chom.2017.12.012.
Infection by Salmonella enterica serovar Typhimurium is accompanied by dysbiosis and a decrease of microbiota-derived butyrate. In this issue of Cell Host & Microbe, Gillis et al. (2018) demonstrate that the lack of butyrate reprograms colonic epithelial metabolism toward lactate fermentation. Lactate is then used as a respiratory electron donor, supporting Salmonella growth and thus promoting infection.
鼠伤寒沙门氏菌感染伴随着肠道菌群失调和微生物衍生丁酸盐的减少。在本期《细胞—宿主与微生物》中，Gillis 等人（2018 年）证明，丁酸盐的缺乏会使结肠上皮代谢向乳酸发酵重编程。然后，乳酸被用作呼吸电子供体，支持沙门氏菌生长，从而促进感染。
Zotero 插件