Division of Psychiatry, Department of Clinical Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
Psychoneuroendocrinology. 2018 Mar;89:53-58. doi: 10.1016/j.psyneuen.2018.01.002. Epub 2018 Jan 4.
Multiple sclerosis (MS) is a neuroinflammatory condition characterized by chronic dysregulation of immune responses leading to repeated episodes of inflammation in the central nervous system. Depression and fatigue are common among MS patients, even in early disease phases, and the disease course can be negatively affected by stressful events. IL-6 and IL-8 have been associated with depression and stressful life events in non-MS patients. The aim of this study was to examine the relationships between depression, fatigue, and exposure to violence, with IL-6 and IL-8 levels in the cerebrospinal fluid (CSF) of MS patients. Levels of IL-6 and -8 were analyzed in the CSF of 47 patients with relapsing-remitting MS. Correlations between IL-6 and IL-8 levels and self-rated depression and fatigue symptoms, as well as clinician-rated history of being exposed to interpersonal violence, were analyzed with correction for age, sex and MS disability status. IL-6 correlated significantly (p < 0.05) with depressive symptoms (adjusted Spearman's ρ = 0.39), fatigue (ρ = 0.39), and exposure to violence in adult life (ρ = 0.35). Depression correlated with both fatigue and being exposed to violence. Associations were not present among patients exposed to disease modifying drugs. In exploratory analyses, the relationship between exposure to violence and IL-6 was non-significant when controlled for depression. Further research should focus on replication of these results, as well as exploring the impact of stressful life events on immune regulation and the clinical characteristics and prognosis of MS patients.
多发性硬化症（MS）是一种神经炎症性疾病，其特征为免疫反应的慢性失调，导致中枢神经系统反复发生炎症。抑郁和疲劳是 MS 患者的常见症状，即使在疾病早期也是如此，而压力事件会对疾病进程产生负面影响。非 MS 患者的 IL-6 和 IL-8 与抑郁和压力生活事件有关。本研究旨在探讨 MS 患者脑脊液（CSF）中 IL-6 和 IL-8 水平与抑郁、疲劳和暴露于暴力之间的关系。对 47 例复发缓解型 MS 患者的 CSF 中 IL-6 和 -8 水平进行了分析。用年龄、性别和 MS 残疾状况校正后，分析了 IL-6 和 IL-8 水平与自我报告的抑郁和疲劳症状以及临床医生评估的人际暴力暴露史之间的相关性。IL-6 与抑郁症状（校正后的 Spearman ρ=0.39）、疲劳（ρ=0.39）和成年期暴露于暴力（ρ=0.35）显著相关（p<0.05）。抑郁与疲劳和暴露于暴力均相关。在接受疾病修正治疗的患者中未发现相关性。在探索性分析中，当控制抑郁时，暴露于暴力与 IL-6 之间的关系无统计学意义。进一步的研究应集中于这些结果的复制，以及探讨生活压力事件对免疫调节以及 MS 患者的临床特征和预后的影响。
