Nherera Leo M, Romanelli Marco, Trueman Paul, Dini Valentina
Smith & Nephew Advanced Wound Management, Hull, UK.
Division of Dermatology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Ostomy Wound Manage. 2017 Dec;63(12):38-47.
Small intestine submucosa (SIS) has been extensively evaluated in preclinical models and developed into commercially produced medical technologies intended for use in several different indications. The SIS extracellular matrix cellular and/or tissue-based product is a commercially available, porcine-derived SIS dressing. The purpose of this review was to consider the role of the SIS dressing in the management of chronic wounds and burns. Using a variety of search terms from the literature to describe the SIS dressing, the following databases were searched: PubMed, York Centre for Reviews and Dissemination database, National Health Service Economic Evaluation database, Health Technology Assessment database, and the Cochrane Library. The search identified 78 studies of which 21 met the inclusion/exclusion criteria. Of those, 14 involved chronic wounds, 3 described the management of burn wounds, and 4 were economic evaluations. The wide variety of comparative treatments and outcomes studied precluded the use of meta-analysis techniques. Study results show SIS dressings may improve outcomes in chronic wounds and cost less than several alternative biological wound treatments. Studies to examine their efficacy in burn wound management are warranted.
小肠黏膜下层（SIS）已在临床前模型中得到广泛评估，并发展成为用于多种不同适应症的商业生产的医疗技术。SIS细胞外基质细胞和/或基于组织的产品是一种市售的猪源SIS敷料。本综述的目的是探讨SIS敷料在慢性伤口和烧伤管理中的作用。使用文献中的各种搜索词来描述SIS敷料，检索了以下数据库：PubMed、约克综述与传播中心数据库、国民健康服务经济评估数据库、卫生技术评估数据库和Cochrane图书馆。检索到78项研究，其中21项符合纳入/排除标准。其中，14项涉及慢性伤口，3项描述了烧伤创面的处理，4项是经济评估。所研究的多种比较治疗方法和结果排除了使用荟萃分析技术的可能性。研究结果表明，SIS敷料可能改善慢性伤口的治疗效果，且成本低于几种替代的生物伤口治疗方法。有必要开展研究以检验其在烧伤创面管理中的疗效。
