Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Neurodegener Dis. 2018;18(1):19-25. doi: 10.1159/000484249. Epub 2018 Jan 12.
BACKGROUND/AIMS: Unlike young-onset Parkinson disease (YOPD), characteristics of late-onset PD (LOPD) have not yet been clearly elucidated. We investigated characteristic features and symptoms related to quality of life (QoL) in LOPD patients.
We recruited drug-naïve, early PD patients. The patient cohort was divided into 3 subgroups based on patient age at onset (AAO): the YOPD group (AAO <50 years), the middle-onset PD (MOPD) group, and the LOPD group (AAO ≥70 years). Using various scales for motor symptoms (MS) and non-MS (NMS) and QoL, we compared the clinical features and impact on QoL.
Of the 132 enrolled patients, 26 were in the YOPD group, 74 in the MOPD group, and 32 in the LOPD group. Among parkinsonian symptoms, patients in the LOPD group had a lower score on the Korean version of the Montreal Cognitive Assessment than the other groups. Logistic regression analysis showed genitourinary symptoms were related to the LOPD group. Linear regression analysis showed both MS and NMS were correlated with QoL in the MOPD group, but only NMS were correlated with QoL in the LOPD group. Particularly, anxiety and fatigue affected QoL in the LOPD group.
LOPD patients showed different characteristic clinical features, and different symptoms were related with QoL for LOPD than YOPD and MOPD patients.
背景/目的：与早发型帕金森病（YOPD）不同，晚发型帕金森病（LOPD）的特征尚未明确阐明。我们研究了 LOPD 患者与生活质量（QoL）相关的特征和症状。
我们招募了未经药物治疗的早期 PD 患者。根据患者发病年龄（AAO）将患者队列分为 3 个亚组：YOPD 组（AAO<50 岁）、中发型 PD（MOPD）组和 LOPD 组（AAO≥70 岁）。使用各种运动症状（MS）和非-MS（NMS）和 QoL 量表，我们比较了临床特征和对 QoL 的影响。
在 132 名入组患者中，26 名患者在 YOPD 组，74 名患者在 MOPD 组，32 名患者在 LOPD 组。在帕金森病症状中，LOPD 组患者的韩国版蒙特利尔认知评估得分低于其他组。逻辑回归分析显示，泌尿生殖系统症状与 LOPD 组有关。线性回归分析显示，MS 和 NMS 均与 MOPD 组的 QoL 相关，但仅 NMS 与 LOPD 组的 QoL 相关。特别是焦虑和疲劳影响了 LOPD 组的 QoL。
LOPD 患者表现出不同的特征性临床特征，与 YOPD 和 MOPD 患者相比，不同的症状与 LOPD 患者的 QoL 相关。
