Acute myeloid leukemia with translocation: A case report and review of the literature.

Chromosomal rearrangement involving the gene is one of the most common genetic alteration in acute myeloid leukemia. A total of 135 different rearrangements have been identified, where 94 translocation partner genes are now characterized at the molecular level. Of these 94 translocation partner genes, 35 translocation partner genes occur recurrently, but only 9 specific gene fusions account for more than 90% of cases. Translocation of with gene at 22q11.2 is rare, with few reported cases in the literature. In this report, we are presenting a case of fusion in de novo acute myeloid leukemia with t(11;22)(q23;q11.2) with a review of the literature.