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移植物抗宿主病患者的晶体性角膜病变异常病程

Unusual Course of Crystalline Keratopathy in a Patient with Graft-Versus-Host Disease.

作者信息

Bostancı Başak, Aydın Akova Yonca

机构信息

Okan University Faculty of Medicine, Department of Ophthalmology, İstanbul, Turkey.

Bayındır Hospital, Ophthalmology Clinic, Ankara, Turkey.

出版信息

Turk J Ophthalmol. 2017 Dec;47(6):344-347. doi: 10.4274/tjo.09582. Epub 2017 Dec 25.

DOI:10.4274/tjo.09582
PMID:29326852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5758770/
Abstract

We present a case of infectious crystalline keratopathy in a patient with Graft-versus-Host disease (GVHD) who developed satellite fungal keratitis. A 51-year-old man was referred for bilateral total persistent corneal epithelial defects with severe dry eye. Although persistent epithelial defect healed with medical therapy, he developed stromal keratitis with satellite lesions confirmed to be secondary to Candida albicans. After three months of antifungal treatment and debridement, improvement of the infiltrates was obtained. Crystalline keratopathy is an important clinical entity which may develop due to several causes. The microbial causes include not only bacteria but fungi as well. Careful investigation must be performed, especially for immune-compromised patients, in order to provide appropriate and timely treatment.

摘要

我们报告了一例患有移植物抗宿主病（GVHD）并发生卫星状真菌性角膜炎的感染性结晶状角膜病变患者。一名51岁男性因双侧持续性角膜上皮全层缺损伴严重干眼前来就诊。尽管持续性上皮缺损经药物治疗愈合，但他仍发生了基质性角膜炎，经证实卫星状病变继发于白色念珠菌。经过三个月的抗真菌治疗和清创，浸润情况有所改善。结晶状角膜病变是一种重要的临床病症，可能由多种原因引起。微生物病因不仅包括细菌，还包括真菌。必须进行仔细检查，尤其是对免疫功能低下的患者，以便提供适当及时的治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e0/5758770/c737684e2a97/TJO-47-344-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e0/5758770/ee491cf5165f/TJO-47-344-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e0/5758770/0839ed8d4896/TJO-47-344-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e0/5758770/b9278cc3ddaf/TJO-47-344-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e0/5758770/22381e4e22d5/TJO-47-344-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e0/5758770/538a1e4c3565/TJO-47-344-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e0/5758770/c737684e2a97/TJO-47-344-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e0/5758770/ee491cf5165f/TJO-47-344-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e0/5758770/0839ed8d4896/TJO-47-344-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e0/5758770/b9278cc3ddaf/TJO-47-344-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e0/5758770/22381e4e22d5/TJO-47-344-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e0/5758770/538a1e4c3565/TJO-47-344-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27e0/5758770/c737684e2a97/TJO-47-344-g6.jpg

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Effects of new biomimetic regenerating agents on corneal wound healing in an experimental model of post-surgical corneal ulcers.新型仿生再生剂对手术性角膜溃疡实验模型中角膜伤口愈合的影响。
Arch Soc Esp Oftalmol. 2015 Oct;90(10):467-74. doi: 10.1016/j.oftal.2015.04.006. Epub 2015 Jun 20.
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Management strategies for persistent epithelial defects of the cornea.角膜持续性上皮缺损的管理策略
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Ocular graft versus host disease following allogeneic stem cell transplantation: a review of current knowledge and recommendations.
异基因干细胞移植后的眼部移植物抗宿主病：当前知识与建议综述
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Ocular graft-versus-host disease.眼移植物抗宿主病。
Curr Opin Allergy Clin Immunol. 2012 Oct;12(5):540-7. doi: 10.1097/ACI.0b013e328357b4b9.
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