Shin Yun-A, Suk Min-Hwa, Jang Hee-Seung, Choi Hye-Jung
Department of Exercise Prescription & Rehabilitation, Dankook University, Cheonan, Korea.
Department of Physical and Rehabilitation Medicine, Samsung Medical Center, Seoul, Korea.
J Exerc Rehabil. 2017 Dec 27;13(6):684-692. doi: 10.12965/jer.1735064.532. eCollection 2017 Dec.
The purpose of this study was to investigate the short-term of Theracurmin dose and exercise type on pain, walking ability, and muscle function in patients with knee osteoarthritis. Twenty-five patients with knee osteoarthritis randomly selected to Theracurmin intake (T) group and Theracurmin in combined with exercise (T+E) group. T group (n= 13) was taken orally a capsule of 700 mg, 3 times per day, (total 2,100 mg, 35 mg/kg-body weight). T+E group (n= 12) performed aerobic training of 30-min walking and weight training for increasing leg muscular strength. After treatment, the number of steps, muscle mass, range of motion of knee, and the muscle strength in flexion and extension significantly increased. The percent body fat, visual analogue scale, The Western Ontario and McMaster score, centers of pressure with closed eye, 10-m walking ability, stair ascending speed were significantly decreased after treatment. Although no difference observed between the T and T+E groups, the 4-week intake of Theracurmin with and without exercise appeared to be effective in reducing the pain and enhancing muscular and balancing function. Therefore, Theracurmin intake for early symptoms and additional exercise as symptoms alleviate might be an effective way of delaying and managing osteoarthritis, and additional studies investigating the effects of Theracurmin and exercise on osteoarthritis could be beneficial.
本研究的目的是调查Theracurmin剂量和运动类型对膝骨关节炎患者疼痛、行走能力和肌肉功能的短期影响。25例膝骨关节炎患者被随机分为Theracurmin摄入（T）组和Theracurmin联合运动（T+E）组。T组（n=13）口服700mg胶囊，每日3次（总量2100mg，35mg/kg体重）。T+E组（n=12）进行30分钟步行的有氧运动和增加腿部肌肉力量的重量训练。治疗后，步数、肌肉量、膝关节活动范围以及屈伸肌肉力量显著增加。治疗后，体脂百分比、视觉模拟评分、西安大略和麦克马斯特评分、闭眼时的压力中心、10米行走能力、上楼梯速度均显著降低。虽然T组和T+E组之间未观察到差异，但4周服用Theracurmin无论是否运动似乎都能有效减轻疼痛并增强肌肉和平衡功能。因此，摄入Theracurmin缓解早期症状并在症状缓解后进行额外运动可能是延缓和管理骨关节炎的有效方法，进一步研究Theracurmin和运动对骨关节炎的影响可能会有所帮助。
