Faltová E, Mráz M, Parízková J, Sedivý J
Physiol Bohemoslov. 1985;34(4):289-96.
The conditions under which increased motor activity leads to raised resistance of the myocardium to injury were studied. Motor activity was raised by running on a treadmill; myocardial resistance was evaluated quantitatively from the extent of isoprenaline (ISO)-induced lesions. After 3 weeks of forced running (5 days a week), using an adequate daily dose, the cardiotoxic effect of ISO was reduced. Adequacy of the daily dose of exercise depended both on the distance run per day and on the rate at which the animals ran. If the training regimen was continued for further weeks, with the same daily dose of exercise, there was no significant increase in protection of the myocardium. In animals aged less than 3 months, myocardial resistance changed after higher daily doses of running than those needed in older animals. The cardioprotective effect of increased motor activity was not conditioned by increase in the weight of the myocardium.
研究了运动活动增加导致心肌对损伤的抵抗力增强的条件。通过在跑步机上跑步来增加运动活动；根据异丙肾上腺素（ISO）诱导的损伤程度定量评估心肌抵抗力。在强制跑步3周（每周5天）后，使用适当的每日剂量，ISO的心脏毒性作用降低。每日运动剂量的适当性既取决于每天跑步的距离，也取决于动物跑步的速度。如果以相同的每日运动剂量将训练方案持续数周，心肌保护作用没有显著增加。在年龄小于3个月的动物中，与年龄较大的动物相比，需要更高的每日跑步剂量才能使心肌抵抗力发生变化。运动活动增加的心脏保护作用并非由心肌重量增加所决定。
