Department of Cardiology, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey.
Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
Biomark Med. 2018 Feb;12(2):141-149. doi: 10.2217/bmm-2017-0197. Epub 2018 Jan 12.
The conflicting relationships of serum omentin with inflammation markers and cardiometabolic disorders were investigated. Results & methods: Unselected 864 population-based middle-aged adults were cross-sectionally studied by sex-specific omentin tertiles. Men in the lowest omentin tertile (T1) had lower systolic blood pressure, HbA1c and glucose values and tended in T3 to higher lipoprotein(a) levels. Logistic regression analysis, adjusted for four covariates, revealed significant independent associations with the presence of hypertension and diabetes only in men. Sex- and age-adjusted odds ratio in gender combined for T2 & T3 versus T1 was 1.34 (95% CI: 1.00-1.79) for metabolic syndrome.
DISCUSSION & CONCLUSION: The elicited adverse relationships of omentin-1 support the notion of oxidative stress-induced proinflammatory conversion of omentin, rendering loss of anti-inflammatory properties.
研究血清网膜素与炎症标志物和心血管代谢紊乱之间的矛盾关系。
通过按性别划分的网膜素三分位法对 864 名未选择的基于人群的中年成年人进行了横断面研究。最低网膜素三分位（T1）的男性收缩压、HbA1c 和血糖值较低，而 T3 脂蛋白（a）水平较高。经过四项协变量调整的逻辑回归分析仅显示出与男性高血压和糖尿病存在显著独立关联。在性别合并的情况下，T2 和 T3 与 T1 相比，代谢综合征的比值比为 1.34（95%CI：1.00-1.79）。
所引出的网膜素-1 的不良关系支持氧化应激诱导的网膜素促炎转化的观点，导致抗炎特性丧失。
