抗球蛋白试验呈阳性的正常个体的随访。

Follow-up of normal individuals with a positive antiglobulin test.

作者信息

Bareford D, Longster G, Gilks L, Tovey L A

出版信息

Scand J Haematol. 1985 Sep;35(3):348-53. doi: 10.1111/j.1600-0609.1985.tb01718.x.

DOI:10.1111/j.1600-0609.1985.tb01718.x

Abstract

Over a period of 20 yr (1962-1982), 67 apparently fit donors at a Regional Blood Transfusion Service were found to have an unexplained positive direct antiglobulin test (DAT). During 1983, 26 were traced and re-tested. 9 still had a positive DAT only 1 of whom had developed autoimmune haemolytic anaemia. 17 had become negative though in 7 of these an autoantibody could still be detected by an enzyme technique. Unlike patients with established autoimmune disorders, the positive DAT individuals were found to have normal T cell subsets though B cells were significantly increased.

摘要

在20年期间（1962 - 1982年），一家地区输血服务中心发现67名看似健康的献血者直接抗球蛋白试验（DAT）呈阳性且原因不明。1983年，对其中26人进行了追踪和重新检测。9人DAT仍为阳性，其中只有1人发展为自身免疫性溶血性贫血。17人DAT转为阴性，不过其中7人仍可通过酶技术检测到自身抗体。与已确诊自身免疫性疾病的患者不同，DAT阳性个体的T细胞亚群正常，不过B细胞显著增多。