State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, P.R. China.
Department of Urinary Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Oncol Rep. 2018 Mar;39(3):883-892. doi: 10.3892/or.2018.6203. Epub 2018 Jan 9.
DEAD-box RNA helicase 3 (DDX3) is a highly conserved family member of DEAD-box proteins in all eukaryotes from yeasts to human beings. Accumulating studies have confirmed DDX3 has the ability to regulate different steps of RNA metabolism, including RNA splicing, RNA export, transcription and translation initiation. Moreover, DDX3 is involved in many biological processes, such as stress response, cell apoptosis, cell cycle regulation and virus infection. In recent years, DDX3 is getting increasing attention due to its essential roles in cancer progression. However, DDX3 role in cancer development is rather complicated. This review mainly focuses on the dual roles of DDX3 and DDX3-mediated signaling pathways in multiple cancers. In addition, the interplaying causes for the controversial roles of DDX3 in cancer are discussed. So far several small molecular chemical compounds targeting DDX3 are also summarized from the anticancer activity to the clinical trials of DDX3 inhibitors.
DEAD-box RNA 解旋酶 3（DDX3）是一种高度保守的 DEAD-box 蛋白家族成员，存在于从酵母到人等所有真核生物中。越来越多的研究证实，DDX3 具有调节 RNA 代谢不同步骤的能力，包括 RNA 剪接、RNA 输出、转录和翻译起始。此外，DDX3 还参与许多生物学过程，如应激反应、细胞凋亡、细胞周期调控和病毒感染。近年来，由于 DDX3 在癌症进展中的重要作用，它越来越受到关注。然而，DDX3 在癌症发展中的作用相当复杂。本综述主要关注 DDX3 及其介导的信号通路在多种癌症中的双重作用。此外，还讨论了导致 DDX3 在癌症中作用争议的相互作用原因。到目前为止，还从抗癌活性到 DDX3 抑制剂的临床试验，总结了几种针对 DDX3 的小分子化学化合物。
