Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Gyeongsang 47392, Republic of Korea.
Mol Med Rep. 2018 Mar;17(3):4846-4852. doi: 10.3892/mmr.2018.8409. Epub 2018 Jan 9.
The prognostic significance of hypoxia inducible factor-1α (HIF-1α) expression in tumors and the levels of preoperative hemoglobin in clear cell renal cell carcinoma (ccRCC), with or without concomitant chronic obstructive pulmonary disease (COPD), was investigated. A total of 128 patients with ccRCC who underwent surgery were analyzed using retrospective methods. Overall survival (OS) and progression free survival (PFS) were analyzed with clinicopathological variables, including preoperative hemoglobin levels, COPD and the levels of HIF‑1α expression, by Kaplan‑Meier survival analysis. Levels of HIF‑1α expression were detected by immunohistochemistry and the multivariate analysis was performed by proportional hazards regression. High levels of HIF‑1α expression were associated with a higher pathological stage and histological grade in patients with ccRCC (P<0.05). The median OS and PFS of patients with concomitant COPD were shorter compared with patients without COPD (P<0.05). The levels of serum hemoglobin, HIF‑1α expression and COPD diagnosis were all identified as independent prognostic variables for the OS and PFS of patients with ccRCC.
本研究旨在探讨肿瘤缺氧诱导因子-1α（HIF-1α）表达和术前血红蛋白水平与合并或不合并慢性阻塞性肺疾病（COPD）的 clear cell renal cell carcinoma（ccRCC）患者预后的关系。采用回顾性方法分析了 128 例接受手术的 ccRCC 患者。通过 Kaplan-Meier 生存分析，用临床病理变量（包括术前血红蛋白水平、COPD 和 HIF-1α表达水平）分析总生存（OS）和无进展生存（PFS）。采用免疫组织化学法检测 HIF-1α表达水平，采用比例风险回归进行多因素分析。结果显示，ccRCC 患者中 HIF-1α表达水平高与较高的病理分期和组织学分级相关（P<0.05）。合并 COPD 的患者的中位 OS 和 PFS 明显短于无 COPD 的患者（P<0.05）。血清血红蛋白水平、HIF-1α表达和 COPD 诊断均被确定为 ccRCC 患者 OS 和 PFS 的独立预后因素。
