Saijo Hiroto, Kilpadi Deepak V, Akita Sadanori
Department of Plastic and Reconstructive Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Active Healing Solutions-Applied Sciences, Kinetic Concepts, Inc, San Antonio, Texas.
Wound Repair Regen. 2017 Nov;25(6):972-975. doi: 10.1111/wrr.12609. Epub 2018 Feb 8.
NPWT with instillation and dwell time (NPWTi-d), which combines NPWT with wound irrigation, has been clinically applied as a more effective treatment than conventional NPWT. Commercially available recombinant human basic fibroblast growth factor (rh-bFGF) has been demonstrated to be beneficial for use over the wound beds. The objective of this study was to evaluate the effectiveness of combined treatment with NPWTi-d and rh-bFGF. Six pigs received 12 full-thickness excisional skin wounds and were treated with six different treatment groups for each pair. The treatment regimens were composed NPWTi-d, NPWT, or advanced wound care with or without rh-bFGF. On day 6, the minimum granulation tissue thickness and blood vessel number of the group of combined treatment with NPWTi-d and rh-bFGF spray were significantly greater than that of the control group. Combined treatment with NPWTi-d and rh-bFGF spray reads to good granulation tissue formation and vascularization for accelerating wound healing.
带滴注和停留时间的负压伤口治疗（NPWTi-d），即将负压伤口治疗与伤口冲洗相结合，已在临床上作为一种比传统负压伤口治疗更有效的治疗方法应用。市售重组人碱性成纤维细胞生长因子（rh-bFGF）已被证明对伤口床有益。本研究的目的是评估NPWTi-d与rh-bFGF联合治疗的有效性。六只猪接受了12个全层切除性皮肤伤口，并对每对伤口用六个不同的治疗组进行治疗。治疗方案包括NPWTi-d、负压伤口治疗，或使用或不使用rh-bFGF的高级伤口护理。在第6天，NPWTi-d与rh-bFGF喷雾联合治疗组的最小肉芽组织厚度和血管数量显著大于对照组。NPWTi-d与rh-bFGF喷雾联合治疗可促进良好的肉芽组织形成和血管化，从而加速伤口愈合。
