Department of Genetics, Department of Psychiatry, and the Hope Center of Washington University School of Medicine, St. Louis, MO 63110, USA.
Department of Genetics, Department of Psychiatry, and the Hope Center of Washington University School of Medicine, St. Louis, MO 63110, USA.
Cell. 2018 Jan 11;172(1-2):10-13. doi: 10.1016/j.cell.2017.12.037.
Psychiatric genetic studies have drawn associations between human cognitive traits and noncoding genomic variants. However, the mechanistic effects of these variants are unclear. By weaving in strands of genomic data from developing human brains, de la Torre-Ubieta et al. tie disease-associated loci to functional enhancers, target genes, and putatively affected cell types.
精神疾病遗传学研究已经在人类认知特征和非编码基因组变异之间建立了关联。然而，这些变异的机制影响尚不清楚。通过将来自发育中人类大脑的基因组数据编织在一起，de la Torre-Ubieta 等人将与疾病相关的基因座与功能增强子、靶基因和可能受影响的细胞类型联系起来。
