Harris County Psychiatric Center, University of Texas Health Science Center at Houston, Houston, TX, United States; Department of Psychiatry and Behavioral Sciences, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, United States.
Harris County Psychiatric Center, University of Texas Health Science Center at Houston, Houston, TX, United States; Department of Psychiatry and Behavioral Sciences, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, United States.
Psychiatry Res. 2018 Mar;261:248-252. doi: 10.1016/j.psychres.2017.12.089. Epub 2018 Jan 3.
Synthetic cannabinoid products have become popular and have led to an increased number of patients presenting to emergency departments and psychiatric hospitals. The purpose of this study was to evaluate the impact of synthetic cannabinoid use at admission on length of stay and doses of antipsychotics at discharge in individuals with bipolar disorder, schizophrenia and other psychotic disorders. We retrospectively examined medical records of 324 inpatients admitted from January 2014 to July 2015. We found that synthetic cannabinoid use predicted length of stay and antipsychotic dose using structural equation modeling. Further, the association of synthetic cannabinoid use with length of stay was partly mediated by antipsychotic dose. These associations were independent of specific diagnosis. In conclusion, patients with bipolar disorder, schizophrenia, or other psychotic disorders who reported synthetic cannabinoid use at admission had shorter length of stay and received lower doses of antipsychotics, irrespective of clinical diagnoses.
合成大麻素产品已广受欢迎，导致越来越多的患者到急诊科和精神病院就诊。本研究旨在评估入院时使用合成大麻素对双相情感障碍、精神分裂症和其他精神病患者的住院时间和出院时抗精神病药物剂量的影响。我们回顾性地检查了 2014 年 1 月至 2015 年 7 月期间入院的 324 名住院患者的病历。我们发现，结构方程模型表明，使用合成大麻素与住院时间和抗精神病药物剂量有关。此外，合成大麻素的使用与住院时间的关联部分由抗精神病药物剂量介导。这些关联与特定诊断无关。总之，入院时报告使用合成大麻素的双相情感障碍、精神分裂症或其他精神病患者的住院时间较短，且接受的抗精神病药物剂量较低，无论临床诊断如何。
