Nagata Shinobu, Seki Yoichi, Shibuya Takayuki, Yokoo Mizue, Murata Tomokazu, Hiramatsu Yoichi, Yamada Fuminori, Ibuki Hanae, Minamitani Noriko, Yoshinaga Naoki, Kusunoki Muga, Inada Yasushi, Kawasoe Nobuko, Adachi Soichiro, Oshiro Keiko, Matsuzawa Daisuke, Hirano Yoshiyuki, Yoshimura Kensuke, Nakazato Michiko, Iyo Masaomi, Nakagawa Akiko, Shimizu Eiji
Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Chiba, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan.
Cognitive Behavioral Therapy Center, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8670, Japan.
BMC Res Notes. 2018 Jan 12;11(1):23. doi: 10.1186/s13104-018-3130-2.
Mental defeat and cognitive flexibility have been studied as explanatory factors for depression and posttraumatic stress disorder. This study examined mental defeat and cognitive flexibility scores in patients with panic disorder (PD) before and after cognitive behavioral therapy (CBT), and compared them to those of a gender- and age-matched healthy control group.
Patients with PD (n = 15) received 16 weekly individual CBT sessions, and the control group (n = 35) received no treatment. Patients completed the Mental Defeat Scale and the Cognitive Flexibility Scale before the intervention, following eight CBT sessions, and following 16 CBT sessions, while the control group did so only prior to receiving CBT (baseline). The patients' pre-CBT Mental Defeat and Cognitive Flexibility Scale scores were significantly higher on the Mental Defeat Scale and lower on the Cognitive Flexibility Scale than those of the control group participants were. In addition, the average Mental Defeat Scale scores of the patients decreased significantly, from 22.2 to 12.4, while their average Cognitive Flexibility Scale scores increased significantly, from 42.8 to 49.5. These results suggest that CBT can reduce mental defeat and increase cognitive flexibility in patients with PD Trial registration The study was registered retrospectively in the national UMIN Clinical Trials Registry on June 10, 2016 (registration ID: UMIN000022693).
心理挫败和认知灵活性已被作为抑郁症和创伤后应激障碍的解释性因素进行研究。本研究考察了惊恐障碍（PD）患者在认知行为疗法（CBT）前后的心理挫败和认知灵活性得分，并将其与性别和年龄匹配的健康对照组进行比较。
15名PD患者接受了为期16周的每周一次的个体CBT治疗，对照组（n = 35）未接受治疗。患者在干预前、8次CBT治疗后以及16次CBT治疗后完成心理挫败量表和认知灵活性量表，而对照组仅在接受CBT之前（基线）完成。患者在CBT治疗前的心理挫败量表得分显著高于对照组，而认知灵活性量表得分显著低于对照组。此外，患者的心理挫败量表平均得分从22.2显著降至12.4，而他们的认知灵活性量表平均得分从42.8显著升至49.5。这些结果表明，CBT可以降低PD患者的心理挫败感并提高认知灵活性。试验注册：该研究于2016年6月10日在日本大学医学情报网络（UMIN）临床试验注册中心进行了回顾性注册（注册号：UMIN000022693）。
