da Mota E Silva Marcelo Soares, da Glória da Costa Carvalho Maria, Moreira Josino Costa, de Oliveira Barreto Emiliano, de Farias Karol Fireman, Nascimento Cristiane Araújo, da Silva Francisca Maria Nunes, de Andrade Tiago Gomes, Luiz Ronir Raggio, de Moura Neto Rodrigo Soares, Ribeiro Fernanda Lattario
Department of Pathology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Center for the Studies on Workers' Health and Human Ecology-Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
BMC Res Notes. 2018 Jan 12;11(1):20. doi: 10.1186/s13104-018-3135-x.
Green Tobacco Sickness (GTS) is an occupational illness caused by dermal absorption of nicotine from tobacco leaves. It affects thousands of farm workers worldwide. Brazil is the second tobacco producer in the world; despite this, there are few studies on GTS among Brazilian harvesters. This study aimed to determine the prevalence of GTS among a population of tobacco workers from a producing area in northeastern Brazil and investigate whether the occurrence of the disease was influenced by factors such age, gender and smoking status. In addition, it was investigated if there was association between the onset of GTS and genetic polymorphisms in genes that encode some detoxification enzymes. A semi-structured questionnaire was used to collect demographic, behavioral and occupational data from the referred workers. Polymorphisms were tested through the Polymerase Chain Reaction technique.
The total prevalence of GTS found was 56.9%, with a significant difference between genders (71.7% for women and 35.3% for men, p < 0.0001). No association was identified between the investigated polymorphisms and GTS. This study confirms the occurrence of GTS among tobacco harvesters in Brazil with high prevalence. The investigation suggests the need to take preventive measures to protect tobacco workers against this disease.
绿烟草病（GTS）是一种因皮肤吸收烟叶中的尼古丁而引发的职业病。它影响着全球数千名农场工人。巴西是世界第二大烟草生产国；尽管如此，针对巴西烟草采摘工人中绿烟草病的研究却很少。本研究旨在确定巴西东北部一个产区的烟草工人中绿烟草病的患病率，并调查该病的发生是否受年龄、性别和吸烟状况等因素的影响。此外，还研究了绿烟草病的发病与一些解毒酶编码基因的遗传多态性之间是否存在关联。使用半结构化问卷收集上述工人的人口统计学、行为和职业数据。通过聚合酶链反应技术检测多态性。
发现绿烟草病的总患病率为56.9%，性别之间存在显著差异（女性为71.7%，男性为35.3%，p < 0.0001）。在所调查的多态性与绿烟草病之间未发现关联。本研究证实巴西烟草采摘工人中存在绿烟草病，且患病率很高。调查表明需要采取预防措施来保护烟草工人免受这种疾病的侵害。
