劳丹诺辛（阿曲库铵的一种代谢产物）可提高兔体内氟烷的最低肺泡浓度。

Laudanosine (a metabolite of atracurium) increases the minimum alveolar concentration of halothane in rabbits.

作者信息

Shi W Z, Fahey M R, Fisher D M, Miller R D, Canfell C, Eger E I

出版信息

Anesthesiology. 1985 Dec;63(6):584-8. doi: 10.1097/00000542-198512000-00006.

DOI:10.1097/00000542-198512000-00006

Abstract

The authors hypothesized that laudanosine, a metabolite of atracurium and a central nervous system stimulant, might increase the minimum alveolar concentration (MAC) of halothane. An initial study in five rabbits anesthetized with halothane used a two-compartment model to produce estimates of pharmacokinetic variables for laudanosine. These estimates were used to determine the rates of infusion that would produce steady state plasma concentrations of laudanosine of approximately 200, 400, and 800 ng . ml-1. Subsequent infusion of laudanosine in eight rabbits produced mean (+/- SD) steady state plasma concentrations of laudanosine of 234 +/- 56, 457 +/- 66, and 873 +/- 105 ng . ml-1. The control value for MAC of halothane was 1.08 +/- 0.28%. At the lowest steady state plasma laudanosine concentration, MAC did not significantly differ from control (MAC = 1.15 +/- 0.23%, P less than 0.1). However, at 457 and 873 ng . ml-1, laudanosine significantly increased the MAC of halothane by 23% and 30%, respectively. Infusion with saline in two additional rabbits did not affect MAC. Therefore, at the plasma concentrations of laudanosine found in humans after administration of atracurium, laudanosine increased the MAC of halothane in rabbits.

摘要

作者们推测，阿曲库铵的代谢产物、一种中枢神经系统兴奋剂劳丹诺辛，可能会增加氟烷的最低肺泡浓度（MAC）。最初在五只接受氟烷麻醉的兔子身上进行的研究，采用二室模型来估算劳丹诺辛的药代动力学变量。这些估算值被用于确定能产生稳态血浆劳丹诺辛浓度分别约为200、400和800 ng·ml⁻¹的输注速率。随后在八只兔子中输注劳丹诺辛，产生的劳丹诺辛平均（±标准差）稳态血浆浓度分别为234±56、457±66和873±105 ng·ml⁻¹。氟烷MAC的对照值为1.08±0.28%。在最低稳态血浆劳丹诺辛浓度时，MAC与对照无显著差异（MAC = 1.15±0.23%，P<0.1）。然而，在457和873 ng·ml⁻¹时，劳丹诺辛分别使氟烷的MAC显著增加了23%和30%。另外两只兔子输注生理盐水并未影响MAC。因此，在人体给予阿曲库铵后所发现的血浆劳丹诺辛浓度下，劳丹诺辛增加了兔子体内氟烷的MAC。