Weldon S T, Perry D F, Cork R C, Gandolfi A J
Anesthesiology. 1985 Dec;63(6):684-7. doi: 10.1097/00000542-198512000-00021.
Sufentanil and its two primary metabolites, N-(4-[methoxymethyl]-4-piperidinyl)-N-phenyl propanamide (MPPP), and N-(4[hydroxymethyl]-1-[2-thienylethyl]-4-piperidinyl)-N-phenyl propanamide (desmethyl sufentanil), were detected by capillary gas chromatography with a nitrogen-phosphorous detector. The detection limit for sufentanil and its metabolites is 30-50 pg/ml with minimal interfering substances in the chromatograms. This method allowed for the detection of serum sufentanil in the terminal elimination phase of sufentanil in a patient receiving 1.5 micrograms/kg and will allow for studies to determine the pharmacokinetics and metabolism of sufentanil in a wide variety of patient groups now receiving this agent.
采用配有氮磷检测器的毛细管气相色谱法检测了舒芬太尼及其两种主要代谢产物，即N-(4-[甲氧基甲基]-4-哌啶基)-N-苯基丙酰胺（MPPP）和N-(4[羟甲基]-1-[2-噻吩基乙基]-4-哌啶基)-N-苯基丙酰胺（去甲舒芬太尼）。舒芬太尼及其代谢产物的检测限为30 - 50 pg/ml，色谱图中的干扰物质极少。该方法能够检测接受1.5微克/千克剂量舒芬太尼的患者体内舒芬太尼终末消除期的血清舒芬太尼含量，并且将有助于开展研究以确定舒芬太尼在目前正在使用该药物的各类患者群体中的药代动力学和代谢情况。
