细胞凋亡蛋白酶机制概述。
A primer on caspase mechanisms.
机构信息
Graduate Program in Biomedical Sciences, NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Graduate Program in Biomedical Sciences, NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
出版信息
Semin Cell Dev Biol. 2018 Oct;82:79-85. doi: 10.1016/j.semcdb.2018.01.002. Epub 2018 Jan 12.
Abstract
Caspases belong to a diverse clan of proteolytic enzymes known as clan CD with highly disparate functions in cell signaling. The caspase members of this clan are only found in animals, and most of them orchestrate the demise of cells by the highly distinct regulated cell death phenotypes known as apoptosis and pyroptosis. This review looks at the mechanistic distinctions between the activity and activation mechanisms of mammalian caspases compared to other members of clan CD. We also compare and contrast the role of different caspase family members that program anti-inflammatory and pro-inflammatory cell death pathways.
摘要
半胱天冬酶属于一个具有高度不同功能的细胞信号蛋白水解酶家族，称为 CD 族。该家族的半胱天冬酶成员仅存在于动物中，它们中的大多数通过高度独特的受调控的细胞死亡表型（称为细胞凋亡和细胞焦亡）来协调细胞的死亡。本综述着眼于哺乳动物半胱天冬酶的活性和激活机制与 CD 族其他成员之间的机制差异。我们还比较和对比了不同半胱天冬酶家族成员在调控抗炎和促炎细胞死亡途径中的作用。
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