Laboratory for Molecular Modeling, UNC Eshelman School of Pharmacy, UNC Chapel Hill, Chapel Hill, NC 27599, USA; ParlezChem, 123 W Union Street, Hillsborough, NC 27278, USA.
Collaborations Pharmaceuticals, 840 Main Campus Drive, Lab 3510, Raleigh, NC 27606, USA.
Drug Discov Today. 2018 Mar;23(3):661-672. doi: 10.1016/j.drudis.2018.01.018. Epub 2018 Jan 9.
We have conducted a bibliometric review of drug repurposing by scanning >25 million papers in PubMed and using text-mining methods to gather, count and analyze chemical-disease therapeutic relationships. We find that >60% of the ∼35,000 drugs or drug candidates identified in our study have been tried in more than one disease, including 189 drugs that have been tried in >300 diseases each. Whereas in the majority of cases these drugs were applied in therapeutic areas close to their original use, there have been striking, and perhaps instructive, successful attempts of drug repurposing for unexpected, novel therapeutic areas.
我们通过扫描 PubMed 中的超过 2500 万篇论文，并使用文本挖掘方法来收集、计数和分析化学-疾病治疗关系，对药物重定位进行了文献计量学回顾。我们发现，在我们的研究中确定的约 35000 种药物或药物候选物中，有超过 60%的药物已经在一种以上的疾病中进行了尝试，其中 189 种药物在 300 多种疾病中进行了尝试。虽然在大多数情况下，这些药物是在与其原始用途相近的治疗领域应用的，但也有一些令人瞩目的、或许具有启发性的药物重定位成功尝试，用于意想不到的新治疗领域。
