Bozkus Fulsen, Dikmen Nursel, Demir Lutfu Saltuk
Department of Chest Diseases, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
Department of Chest Diseases, Necip Fazıl State Hospital, Kahramanmaras, Turkey.
Clin Respir J. 2018 May;12(5):1964-1973. doi: 10.1111/crj.12765. Epub 2018 Feb 12.
Chronic intermittent hypia, inflammation and oxidative stress are involved in resultant obstructive sleep apnea syndrome (OSAS), which may affect numerous regulatory mechanisms that play a role in the regulation of blood pressure. Gamma-glutamyl transferase (GGT) is a novel marker in the prediction of cardiovascular risk.
The objective of this study was to investigate the correlation of serum levels of GGT with hypertension and the degree of the upper airway obstruction in subjects with OSAS.
A total of 270 subjects that met the inclusion criteria were enrolled in the study. The subjects were divided into four separate groups according to the apnea-hypopnea index (AHI) scores as the control group (AHI < 5), mild OSAS group (AHI 5-15), moderate OSAS group (AHI 16-30) and severe OSAS group (AHI >30). A further classification of the OSAS subjects was made in two groups based on the presence of hypertension.
The study included 43 control individuals and 59 subjects with mild, 54 subjects with moderate and 114 subjects with severe OSAS. The serum levels of GGT were found to be significantly correlated with OSAS severity (control group: 18 ± 3.3, mild OSAS: 23.6 ± 7.3, moderate OSAS: 26.4 ± 7.5 and severe OSAS: 39.8 ± 12). Serum levels of GGT were found to be significantly higher in OSAS subjects with concomitant hypertension than in the group without associated hypertension (P < .05). The results showed that the adjusted mean GGT under OSA without hypertension (M = 28.76, SE = 0.71) was significantly lower than in cases with OSA with hypertension (M = 42.79, SE = 1.19).
The present study indicated a strong correlation between high serum levels of GGT and concomitant hypertension in subjects with obstructive sleep apnea. This biomarker may be helpful in grading the severity of obstructive sleep apnea and correlated with hypertension in this population.
慢性间歇性低氧、炎症和氧化应激与阻塞性睡眠呼吸暂停综合征（OSAS）的发生有关，这可能会影响众多参与血压调节的调控机制。γ-谷氨酰转移酶（GGT）是预测心血管风险的一种新标志物。
本研究旨在探讨阻塞性睡眠呼吸暂停综合征患者血清GGT水平与高血压及上气道阻塞程度的相关性。
共纳入270例符合纳入标准的受试者。根据呼吸暂停低通气指数（AHI）评分将受试者分为四组，即对照组（AHI<5）、轻度OSAS组（AHI 5 - 15）、中度OSAS组（AHI 16 - 30）和重度OSAS组（AHI>30）。根据是否患有高血压，将OSAS受试者进一步分为两组。
本研究纳入43名对照个体，59名轻度OSAS受试者，54名中度OSAS受试者和114名重度OSAS受试者。发现血清GGT水平与OSAS严重程度显著相关（对照组：18±3.3，轻度OSAS：23.6±7.3，中度OSAS：26.4±7.5，重度OSAS：39.8±12）。发现伴有高血压的OSAS受试者血清GGT水平显著高于无相关高血压的组（P<0.05）。结果显示，无高血压的OSA患者调整后的平均GGT（M = 28.76，SE = 0.71）显著低于伴有高血压的OSA患者（M = 42.79，SE = 1.19）。
本研究表明，阻塞性睡眠呼吸暂停患者血清GGT水平升高与伴有高血压密切相关。这种生物标志物可能有助于对阻塞性睡眠呼吸暂停的严重程度进行分级，并与该人群的高血压相关。
