Atomic and Molecular Collisions Laboratory, CEFITEC, Department of Physics, Universidade NOVA de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal.
School of Physical Sciences, The Open University, Walton Hall, MK7 6AA Milton Keynes, United Kingdom.
J Chem Phys. 2018 Jan 14;148(2):021101. doi: 10.1063/1.5018401.
This work demonstrates that selective excision of hydrogen atoms at a particular site of the DNA base adenine can be achieved in collisions with electronegative atoms by controlling the impact energy. The result is based on analysing the time-of-flight mass spectra yields of potassium collisions with a series of labeled adenine derivatives. The production of dehydrogenated parent anions is consistent with neutral H loss either from selective breaking of C-H or N-H bonds. These unprecedented results open up a new methodology in charge transfer collisions that can initiate selective reactivity as a key process in chemical reactions that are dominant in different areas of science and technology.
这项工作表明，通过控制撞击能量，可以在与电负性原子的碰撞中实现对 DNA 碱基腺嘌呤特定位置的氢原子的选择性去除。该结果基于对钾与一系列标记腺嘌呤衍生物碰撞的飞行时间质谱产率的分析。脱氢母体阴离子的产生与中性 H 的损失一致，要么是通过选择性地打破 C-H 或 N-H 键。这些前所未有的结果为电荷转移碰撞开辟了一种新的方法，这种方法可以引发选择性反应，作为化学反应中的关键过程，这些反应在科学技术的不同领域占据主导地位。
