使用超声弹性成像评估舒张功能
Assessment of Diastolic Function Using Ultrasound Elastography.
作者信息
Vejdani-Jahromi Maryam, Freedman Jenna, Kim Young-Joong, Trahey Gregg E, Wolf Patrick D
机构信息
Biomedical Engineering Department, Duke University, Durham, NC, USA.
Biomedical Engineering Department, Duke University, Durham, NC, USA.
出版信息
Ultrasound Med Biol. 2018 Mar;44(3):551-561. doi: 10.1016/j.ultrasmedbio.2017.11.011. Epub 2018 Jan 10.
Shear wave elasticity imaging (SWEI) is a novel ultrasound elastography technique for assessing tissue stiffness. In this study, we investigate the potential of SWEI for providing diastolic functional assessment. In 11 isolated rabbit hearts, pressure-volume (PV) measurements were recorded simultaneously with SWEI recordings from the left ventricle free wall before and after induction of global ischemia. PV-based end diastolic stiffness increased by 100% after ischemia (p <0.05), and SWEI stiffness showed an increase of 103% (p <0.05). The relaxation time constant (τ) before and after ischemia derived from pressure and SWEI curves showed increases of 79% and 76%, respectively (p <0.05). A linear regression between pressure-derived and SWEI-based (τ) showed a slope of 1.164 with R = 0.80, indicating the near equivalence of the two assessments. SWEI can be used to derive (τ) values and myocardial end diastolic stiffness. In global conditions, these measurements are consistent with PV measurements of diastolic function.
剪切波弹性成像（SWEI）是一种用于评估组织硬度的新型超声弹性成像技术。在本研究中，我们探究了SWEI在提供舒张功能评估方面的潜力。在11个离体兔心脏中，在诱导全心缺血前后，同步记录了压力-容积（PV）测量值以及来自左心室游离壁的SWEI记录。基于PV的舒张末期硬度在缺血后增加了100%（p<0.05），而SWEI硬度增加了103%（p<0.05）。从压力和SWEI曲线得出的缺血前后的舒张时间常数（τ）分别增加了79%和76%（p<0.05）。基于压力和基于SWEI的（τ）之间的线性回归显示斜率为1.164，R=0.80，表明两种评估近乎等效。SWEI可用于得出（τ）值和心肌舒张末期硬度。在整体情况下，这些测量结果与舒张功能的PV测量结果一致。
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