Brater D C, Anderson S A, Brown-Cartwright D, Toto R D, Chen A, Jacob G B
Clin Pharmacol Ther. 1985 Dec;38(6):674-9. doi: 10.1038/clpt.1985.244.
Twenty subjects (10 with normal renal function and 10 with moderate renal insufficiency) participated in an 8-day study to assess the effects of acute and chronic etodolac dosing on renal function. Subjects and patients were hospitalized and followed a controlled diet (150 mEq sodium, 60 to 80 mEq potassium) during the study. A 3-day drug-free period was followed by 4 days of etodolac, 200 mg b.i.d. Sodium balance and body weight remained unchanged in both groups. Modest reductions in renal function as measured by clearances of inulin and p-aminohippurate occurred acutely only in the patients with renal impairment. Chronic therapy resulted in no decrements in daily creatinine clearance. In an average effective anti-inflammatory dose, etodolac did not produce a sustained effect on renal function in either normal subjects or patients with moderate renal insufficiency.
二十名受试者（10名肾功能正常者和10名中度肾功能不全者）参与了一项为期8天的研究，以评估急性和慢性服用依托度酸对肾功能的影响。在研究期间，受试者和患者均住院并遵循控制饮食（150 mEq钠，60至80 mEq钾）。经过3天的无药期后，进行4天的依托度酸给药，每日两次，每次200 mg。两组的钠平衡和体重均保持不变。仅在肾功能损害患者中，急性服用依托度酸后，菊粉和对氨基马尿酸清除率所测得的肾功能出现适度下降。慢性治疗并未导致每日肌酐清除率降低。在平均有效抗炎剂量下，依托度酸对正常受试者或中度肾功能不全患者的肾功能均未产生持续影响。
