Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital London NHS Trust, London, United Kingdom.
University College London Great Ormond Street Institute of Child Health, London, United Kingdom.
Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):94-99. doi: 10.1167/iovs.17-22984.
Our aim was to elaborate how on and off signals contribute to pattern ERGs and pattern visual evoked potentials (VEPs) by using pedestal patterns arising from incremental and decremental onset stimulation.
Pattern onset/offset ERGs and VEPs were produced by black and white checks of 60' side length and 88% spatial contrast appearing in a 16° field for 200 ms from white (110 cd/m2), black (7 cd/m2), and gray (48 cd/m2) backgrounds and disappeared for 1000 ms. Twenty healthy subjects participated in the study (median age 19.5, range, 5-31 years), 10 of whom also underwent pattern onset/offset ERG recordings to the same stimuli (median age 25.7, range, 22-31 years). VEPs were recorded from an occipital array referred to Fz. Pattern electroretinograms (PERGs) were recorded from "Dawson-Trick-Litzkow" (DTL) plus corneal electrodes referred to ipsilateral outer canthi.
There was high correlation within subjects of the VEP waveform produced by patterns arising from light increment and decrement (group mean correlation coefficient of PVEPs to check appearance from black versus white: 87%). An average of increment and decrement PERGs simulated the onset PERG from a gray background. This waveform is akin to standard International Society for Clinical Electrophysiology of Vision (ISCEV) clinical PERGs to reversing checks.
In healthy individuals, the early components of the pattern onset/offset VEP waveforms are comparable to light increment and decrement pedestal stimulation. Pattern onset/offset ERGs to pedestal stimulation may be used to probe simultaneous recording of ERGs with VEPs in order to obtain an assessment of retinal ganglion cell and optic pathway function in patients with less stable fixation.
我们旨在通过使用来自递增和递减起始刺激的基底图案，阐述 ON 和 OFF 信号如何导致图案 ERG 和图案视觉诱发电位（VEP）。
黑白棋盘格的长度为 60'，空间对比度为 88%，出现在 16°的视野中，持续 200 毫秒，背景为白色（110 cd/m2）、黑色（7 cd/m2）和灰色（48 cd/m2），消失 1000 毫秒。20 名健康受试者参加了这项研究（中位数年龄 19.5 岁，范围 5-31 岁），其中 10 名受试者还接受了相同刺激的图案起始/终止 ERG 记录（中位数年龄 25.7 岁，范围 22-31 岁）。VEP 从枕区记录，参考 Fz。图案视网膜电图（PERG）从“道森-特里克-利茨科夫”（DTL）加角膜电极记录，参考同侧外眼角。
来自光增量和减量的图案产生的 VEP 波形在受试者之间具有高度相关性（组内 PVEPs 从黑色到白色的平均相关系数：87%）。增量和减量 PERG 的平均值模拟了灰色背景下的起始 PERG。这个波形类似于标准国际临床视觉电生理学会（ISCEV）对反转检查的临床 PERG。
在健康个体中，图案起始/终止 VEP 波形的早期成分与光增量和减量基底刺激相当。基底刺激的图案起始/终止 ERG 可用于探测 ERG 与 VEP 的同时记录，以便在固定稳定性较差的患者中评估视网膜神经节细胞和视神经通路功能。
