Coleman D L
Endocrinology. 1985 Dec;117(6):2279-83. doi: 10.1210/endo-117-6-2279.
Two metabolites of the adrenal steroid dehydroepiandrosterone (DHEA), 3 alpha-hydroxyetiocholanolone and 3 beta-hydroxyetiocholanolone, were found to have antiobesity properties with respect to both prevention of the development of obesity as well as weight reduction after obesity was established. All of the obesity types studied responded to metabolite therapy to a greater or lesser extent. The more natural obesity seen in certain strains of mice with aging responded most rapidly to the feeding of either metabolite. The effective dosage (0.1%) fed in the diet was only one quarter the dosage required for DHEA to produce the same effect in preventing diabetes symptoms in C57BL/Ks diabetic (db) mutant mice. Unlike DHEA, neither metabolite produced any undesirable estrogenic or androgenic side-effects. 3 alpha-hydroxyethiocholanolone and 3 beta-hydroxyetiocholanolone, formerly considered only as inert end products of steroid metabolism, have beneficial actions in mice with various diabetes-obesity conditions and may be metabolic effectors in their own right.
肾上腺类固醇脱氢表雄酮（DHEA）的两种代谢产物，3α-羟基雄甾烷酮和3β-羟基雄甾烷酮，被发现具有抗肥胖特性，既可以预防肥胖的发展，也可以在肥胖形成后减轻体重。所有研究的肥胖类型对代谢产物治疗都有不同程度的反应。在某些衰老小鼠品系中出现的更自然的肥胖对喂食任何一种代谢产物的反应最为迅速。饮食中喂食的有效剂量（0.1%）仅为DHEA在预防C57BL/Ks糖尿病（db）突变小鼠糖尿病症状时产生相同效果所需剂量的四分之一。与DHEA不同，这两种代谢产物都不会产生任何不良的雌激素或雄激素副作用。3α-羟基雄甾烷酮和3β-羟基雄甾烷酮，以前仅被视为类固醇代谢的惰性终产物，在患有各种糖尿病肥胖症的小鼠中具有有益作用，并且可能本身就是代谢效应物。
