Nalda M A, Gomar C, Luis M
Eur J Anaesthesiol. 1985 Sep;2(3):265-77.
Two homogeneous groups of 20 healthy women submitted to elective gynaecological surgery, who presented after anaesthesia with peripheral vasoconstriction and shivering, were included in a randomized, double-blind study. The first group received 10 mg ketanserin, a new pure antagonist of serotoninergic S2 receptors. The second group received 10 ml saline as placebo. Blood pressure, heart rate, pulse wave amplitude, and rectal and cutaneous temperatures were measured before and 5, 15 and 30 min after treatment. Vasoconstriction, shivering and discomfort were classified as intense, moderate or absent at these times. Venous and arterial blood gases were determined before and 15 min after treatment. Blood pressure and heart rate decreased slightly after ketanserin administration and this decrease was statistically significant. Increases in rectal temperature were similar in both groups. Peripheral temperature, measured in the big toe, significantly decreased in the placebo group but did not change after ketanserin. Vasoconstriction, shivering, discomfort and pulse wave amplitude improved significantly following ketanserin. We conclude that ketanserin may be effective in treating this post-operative complication, the possible mechanism being the vasodilatation it causes; a central serotoninergic blockade could also be implied.
两组各20名接受择期妇科手术的健康女性纳入一项随机双盲研究，她们在麻醉后出现外周血管收缩和寒战。第一组接受10毫克酮色林，一种新型的5-羟色胺能S2受体纯拮抗剂。第二组接受10毫升生理盐水作为安慰剂。在治疗前以及治疗后5、15和30分钟测量血压、心率、脉搏波振幅、直肠温度和皮肤温度。此时将血管收缩、寒战和不适分为严重、中度或无。在治疗前和治疗后15分钟测定静脉和动脉血气。给予酮色林后血压和心率略有下降，且这种下降具有统计学意义。两组直肠温度升高相似。在安慰剂组中，大脚趾测量的外周温度显著下降，但酮色林治疗后未改变。酮色林治疗后血管收缩、寒战、不适和脉搏波振幅显著改善。我们得出结论，酮色林可能有效治疗这种术后并发症，其可能机制是它引起的血管舒张；也可能涉及中枢5-羟色胺能阻滞。
