Sawamura Soichiro, Jinnin Masatoshi, Kajihara Ikko, Makino Katsunari, Aoi Jun, Ichihara Asako, Makino Takamitsu, Fukushima Satoshi, Ihn Hironobu
Department of Dermatology and Plastic Surgery, Faculty of life Sciences, Kumamoto University.
Drug Discov Ther. 2017;11(6):342-345. doi: 10.5582/ddt.2017.01059.
These days various collagen supplements have widely been marketed. However, it has not been scientifically proved whether increasing collagen can actually prevent skin aging. Systemic sclerosis (SSc) is an autoimmune disease that is characterized by thickening of the skin caused by accumulation of collagen. In this study, we tried to evaluate facial skin characteristics and skin aging of SSc patients by using digital imaging system. As the result, the severity of wrinkles, texture and pores were significantly lower in SSc patients than control subjects. Among them, wrinkles showed better correlation with skin thickness score. Therefore, increased amount of collagen in scleroderma skin may directly affect wrinkles. In conclusion, attempt on collagen induction itself is reasonable and effective strategy in order to keep young appearance, although oral collagen supplementation may not directly reach to the skin.
如今，各种胶原蛋白补充剂已广泛上市。然而，增加胶原蛋白是否真的能预防皮肤衰老尚未得到科学证实。系统性硬化症（SSc）是一种自身免疫性疾病，其特征是由于胶原蛋白堆积导致皮肤增厚。在本研究中，我们试图使用数字成像系统评估SSc患者的面部皮肤特征和皮肤衰老情况。结果显示，SSc患者的皱纹、质地和毛孔严重程度明显低于对照组。其中，皱纹与皮肤厚度评分的相关性更好。因此，硬皮病皮肤中胶原蛋白含量的增加可能直接影响皱纹。总之，尽管口服补充胶原蛋白可能无法直接作用于皮肤，但尝试诱导胶原蛋白本身是保持年轻外表的合理且有效的策略。
