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磷酸化α-突触核蛋白-铜复合物的形成在帕金森病发病机制中的作用

Phosphorylated -Synuclein-Copper Complex Formation in the Pathogenesis of Parkinson's Disease.

作者信息

Castillo-Gonzalez Juan Antonio, Loera-Arias Maria De Jesus, Saucedo-Cardenas Odila, Montes-de-Oca-Luna Roberto, Garcia-Garcia Aracely, Rodriguez-Rocha Humberto

机构信息

Departamento de Histologia, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, 64460 Monterrey, NL, Mexico.

Centro de Investigaciones Biomedicas del Noreste, Monterrey, NL, Mexico.

出版信息

Parkinsons Dis. 2017;2017:9164754. doi: 10.1155/2017/9164754. Epub 2017 Nov 23.

DOI:10.1155/2017/9164754
PMID:29333317
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5733240/
Abstract

Parkinson's disease is the second most important neurodegenerative disorder worldwide. It is characterized by the presence of Lewy bodies, which are mainly composed of -synuclein and ubiquitin-bound proteins. Both the ubiquitin proteasome system (UPS) and autophagy-lysosomal pathway (ALS) are altered in Parkinson's disease, leading to aggregation of proteins, particularly -synuclein. Interestingly, it has been observed that copper promotes the protein aggregation process. Additionally, phosphorylation of -synuclein along with copper also affects the protein aggregation process. The interrelation among -synuclein phosphorylation and its capability to interact with copper, with the subsequent disruption of the protein degradation systems in the neurodegenerative process of Parkinson's disease, will be analyzed in detail in this review.

摘要

帕金森病是全球第二重要的神经退行性疾病。其特征是存在路易小体，路易小体主要由α-突触核蛋白和泛素结合蛋白组成。在帕金森病中，泛素蛋白酶体系统（UPS）和自噬-溶酶体途径（ALS）均发生改变，导致蛋白质聚集，尤其是α-突触核蛋白的聚集。有趣的是，已观察到铜会促进蛋白质聚集过程。此外，α-突触核蛋白的磷酸化以及铜也会影响蛋白质聚集过程。本综述将详细分析α-突触核蛋白磷酸化与其与铜相互作用的能力之间的相互关系，以及随后在帕金森病神经退行性过程中蛋白质降解系统的破坏。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a64e/5733240/32000c7e8c16/PD2017-9164754.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a64e/5733240/c756bb64af51/PD2017-9164754.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a64e/5733240/3abef9c17c4d/PD2017-9164754.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a64e/5733240/32000c7e8c16/PD2017-9164754.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a64e/5733240/c756bb64af51/PD2017-9164754.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a64e/5733240/3abef9c17c4d/PD2017-9164754.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a64e/5733240/32000c7e8c16/PD2017-9164754.003.jpg

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