多克隆B细胞激活剂通过增强抗半抗原抗体的产生来抑制小鼠对恶唑酮的接触敏感性，这些抗半抗原抗体诱导通过可溶性因子释放起作用的抑制性T淋巴细胞。
Polyclonal B cell activators inhibit contact sensitivity to oxazolone in mice by potentiating the production of anti-hapten antibodies that induce T suppressor lymphocytes acting through the release of soluble factors.
作者信息
Campa M, De Libero G, Benedettini G, Mori L, Angioni M R, Marelli P, Falcone G
出版信息
Int Arch Allergy Appl Immunol. 1985;78(4):391-5. doi: 10.1159/000233919.
Polyclonal B cell activators (PBAs) such as purified protein derivative, lipopolysaccharide, Staphylococcus aureus strain Cowan I (StaCwI), and Pseudomonas aeruginosa inhibit contact sensitivity to oxazolone in mice when given 24 h before sensitization. This suppression, transferable from immunodepressed animals to oxazolone-sensitized recipients with immune serum, has been shown to be due to the early appearance of anti-hapten antibodies. These antibodies elicit T suppressor cells which release soluble factor(s) capable of inhibiting the passive transfer of contact sensitivity.
多克隆B细胞激活剂（PBAs），如纯化蛋白衍生物、脂多糖、金黄色葡萄球菌考恩I株（StaCwI）和铜绿假单胞菌，在致敏前24小时给予小鼠时，可抑制对恶唑酮的接触敏感性。这种抑制作用可通过免疫血清从免疫抑制动物转移至恶唑酮致敏的受体，已证明这是由于抗半抗原抗体的早期出现所致。这些抗体引发T抑制细胞，后者释放能够抑制接触敏感性被动转移的可溶性因子。
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