卡拉黄素A - C，从[植物名称]根中分离得到的三种新的呫吨酮及其细胞毒性。 （注：原文中“from the roots of ”后面缺少植物名称）
Calaxanthones A-C, three new xanthones from the roots of and the cytotoxicity.
作者信息
Laopian Fuengfa, Kaennakam Sutin, Rassamee Kitiya, Siripong Pongpun, Tip-Pyang Santi
机构信息
a Faculty of Science, Department of Chemistry, Center of Excellence in Natural Products Chemistry , Chulalongkorn University , Bangkok , Thailand.
b Natural Products Research Section, Research Division , National Cancer Institute , Bangkok , Thailand.
出版信息
Nat Prod Res. 2019 Jun;33(11):1584-1590. doi: 10.1080/14786419.2018.1425849. Epub 2018 Jan 15.
Three new xanthones, named calaxanthones AC (-), along with 17 known xanthones (-) were isolated from the roots of . Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicity against five cancer cell lines (KB, HeLa S-3, HT-29, MCF-7 and HepG-2). Compound showed potent cytotoxicity against all the five cancer cell lines with IC values in the range of 0.82-5.04 μM. Furthermore, compound showed potent cytotoxicity against KB, HeLa S-3 and HepG2 cells with IC values of 7.06, 5.27 and 9.64 μM, respectively. Additionally, compound showed potent cytotoxicity against KB cell with an IC value of 4.62 μM.
从……的根部分离出三种新的呫吨酮，命名为卡拉呫吨酮AC（-），以及17种已知的呫吨酮（-）。通过光谱分析确定了它们的结构。对所有分离出的化合物针对五种癌细胞系（KB、HeLa S-3、HT-29、MCF-7和HepG-2）进行了细胞毒性评估。化合物……对所有五种癌细胞系均显示出强效细胞毒性，IC值在0.82 - 5.04 μM范围内。此外，化合物……对KB、HeLa S-3和HepG2细胞显示出强效细胞毒性，IC值分别为7.06、5.27和9.64 μM。另外，化合物……对KB细胞显示出强效细胞毒性，IC值为4.62 μM。
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