来自海棠果的细胞毒性异戊烯基呫吨酮。

Cytotoxic prenylated xanthones from Calophyllum inophyllum.

作者信息

Xiao Qi, Zeng Yan-Bo, Mei Wen-Li, Zhao You-Xing, Deng Yuan-Yuan, Dai Hao-Fu

机构信息

Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China.

出版信息

J Asian Nat Prod Res. 2008 Sep-Oct;10(9-10):993-7. doi: 10.1080/10519990802240387.

DOI:10.1080/10519990802240387

PMID:19003621

Abstract

A new prenylated xanthone (1), named caloxanthone N, together with two known constituents, gerontoxanthone C (2) and 2-hydroxyxanthone (3), was isolated from the ethanolic extract of the twigs of Calophyllum inophyllum. Their structures were completely elucidated using a combination of 1D, 2D NMR techniques (COSY, HMQC, HMBC, and ROESY) and HR-ESI-MS analyses. Compounds 1 and 2 exhibited cytotoxicity against chronic myelogenous leukemia cell line (K562) with IC50 values of 7.2 and 6.3 microg ml(- 1), respectively.

摘要

从红厚壳树枝的乙醇提取物中分离出一种新的异戊烯基呫吨酮（1），命名为caloxanthone N，以及两种已知成分，老年呫吨酮C（2）和2 - 羟基呫吨酮（3）。通过结合一维、二维核磁共振技术（COSY、HMQC、HMBC和ROESY）以及高分辨电喷雾电离质谱分析，完全阐明了它们的结构。化合物1和2对慢性髓性白血病细胞系（K562）表现出细胞毒性，IC50值分别为7.2和6.3微克/毫升（-1）。