Ansseau M, Reynolds C F, Kupfer D J, Doumont A, Geenen V, Dresse A E, Juorio A V
J Clin Psychopharmacol. 1985 Dec;5(6):347-9.
A 35-year-old woman with depression attempted suicide by taking an overdose of zimelidine (5 g), which was confirmed by zimelidine and norzimelidine plasma levels. Physical examination and repeat EKGs performed 2, 6, 9, and 12 hours later showed no alteration in her level of consciousness and only a slight increase in QT duration. However, the patient exhibited a distinct extrapyramidal syndrome, a finding consistent with animal data suggesting that zimelidine may possess some dopamine-receptor blockade properties.
一名35岁的抑郁症女性过量服用齐美利定（5克）企图自杀，齐美利定和去甲齐美利定的血浆水平证实了这一点。在服药2、6、9和12小时后进行的体格检查和重复心电图检查显示，她的意识水平没有改变，QT间期仅略有增加。然而，该患者出现了明显的锥体外系综合征，这一发现与动物数据一致，表明齐美利定可能具有一些多巴胺受体阻断特性。
