Department of Otorhinolaryngology-Head and Neck Surgery, Albert Einstein College of Medicine, Bronx, NY.
Int Forum Allergy Rhinol. 2018 Apr;8(4):522-529. doi: 10.1002/alr.22085. Epub 2018 Jan 15.
There is a paucity of data supporting antibiotic use in endoscopic sinus surgery (ESS). The objective of this study is to determine perioperative antibiotic use patterns and factors which influence use in ESS.
An online-based survey was distributed to members of the American Rhinologic Society (ARS). Outcomes included timing of perioperative antibiotic use, practice environment, years of experience, and patient factors that influenced antibiotic use.
There were 204 responses (response rate 18.3%); 36.8% of respondents were in academic positions, 32.8% were in private practice, and 30.4% were in academic-affiliated private practice; 20.6% routinely gave preoperative antibiotics, most commonly to reduce bacterial burden (59.5%) and mucosal inflammation (59.5%); 54.4% routinely gave intraoperative antibiotics, most commonly to reduce the risk of postoperative infection (63.1%); 62.3% routinely gave postoperative antibiotics, citing the need to reduce the risk of postoperative infection (75.6%). Diagnosis influenced postoperative antibiotic use in 63.0%. Preoperative antibiotics were more likely to be prescribed by respondents with more than 5 years of experience (odds ratio [OR] 2.97; 95% confidence interval [CI], 1.04 to 8.54; p = 0.043). Compared to private practitioners, academicians were more likely to give intraoperative antibiotics (OR 2.68; 95% CI, 1.39 to 5.17; p = 0.003), but not preoperative or postoperative antibiotics. Use of nonabsorbable packing was significantly associated with use of postoperative antibiotics (OR 2.01; 95% CI, 1.07 to 3.77; p = 0.031).
This study demonstrates the significant variation in perioperative antibiotic use among otolaryngologists. These results provide support for the establishment of evidence-based practice guidelines for perioperative antibiotic use in ESS.
目前支持内镜鼻窦手术(ESS)中使用抗生素的数据很少。本研究的目的是确定 ESS 中围手术期抗生素使用模式和影响使用的因素。
一项基于网络的调查分发给美国鼻科学会(ARS)的成员。结果包括围手术期抗生素使用的时间、实践环境、经验年限以及影响抗生素使用的患者因素。
共收到 204 份回复(回复率为 18.3%);36.8%的受访者在学术岗位,32.8%在私人诊所,30.4%在学术附属私人诊所;20.6%的人常规给予术前抗生素,最常见的是降低细菌负荷(59.5%)和黏膜炎症(59.5%);54.4%的人常规给予术中抗生素,最常见的是降低术后感染风险(63.1%);62.3%的人常规给予术后抗生素,理由是需要降低术后感染风险(75.6%)。诊断影响 63.0%的术后抗生素使用。有超过 5 年经验的受访者更有可能开术前抗生素(优势比[OR] 2.97;95%置信区间[CI],1.04 至 8.54;p=0.043)。与私人执业者相比,学者更有可能给予术中抗生素(OR 2.68;95%CI,1.39 至 5.17;p=0.003),但不会给予术前或术后抗生素。使用不可吸收填塞物与术后使用抗生素显著相关(OR 2.01;95%CI,1.07 至 3.77;p=0.031)。
本研究表明耳鼻喉科医生围手术期抗生素使用存在显著差异。这些结果为建立 ESS 围手术期抗生素使用的循证实践指南提供了支持。