Revel-Vilk Shoshana, Naamad Mira
Pediatric Hematology, Shaare Zedek Medical Center, affiliated with Hebrew University Medical School, Jerusalem, Israel.
Gaucher Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
Isr J Health Policy Res. 2018 Jan 15;7(1):8. doi: 10.1186/s13584-018-0204-5.
Red blood cell (RBC) transfusions save lives and improve health; however, unnecessary transfusion practice exposes patients to immediate and long-term negative consequences. Indirect consequences of unnecessary transfusions are the reduced availability of RBC units for patients who are in need. Accumulating evidence shows that restricting RBC transfusions improves outcomes and current guidelines suggest limiting RBC transfusion to the minimum number of units required to relieve symptoms of anemia or to return the patient to a safe hemoglobin range (7-8 g/dl in stable, non-cardiac inpatients). Still, studies show that there is over-utilization of RBC transfusion, partly due to low level of knowledge of physicians regarding restrictive RBC transfusion policy across a broad range of professions and specialties. Patient blood management (PBM) programs have been developed to promote clear hospital transfusion guidelines, strive for optimization of patient hemoglobin and iron stores and, most importantly, improve education regarding restrictive RBC policy. Understanding what and where the gaps of knowledge are, as was done in the study by Dr. Koren and his colleagues, is an important step for developing effective PBM programs.
红细胞(RBC)输血可挽救生命并改善健康状况;然而,不必要的输血行为会使患者面临即时和长期的负面后果。不必要输血的间接后果是,有需求的患者可获得的红细胞单位数量减少。越来越多的证据表明,限制红细胞输血可改善治疗效果,当前指南建议将红细胞输血限制在缓解贫血症状或使患者血红蛋白恢复到安全范围(稳定的非心脏住院患者为7 - 8 g/dl)所需的最少单位数。尽管如此,研究表明红细胞输血仍存在过度使用的情况,部分原因是广泛的专业和专科领域的医生对限制性红细胞输血政策的了解程度较低。已制定患者血液管理(PBM)计划,以推广明确的医院输血指南,力求优化患者的血红蛋白和铁储备,最重要的是,加强关于限制性红细胞政策的教育。正如科伦博士及其同事的研究所做的那样,了解知识差距所在及情况,是制定有效的患者血液管理计划的重要一步。