Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110112, Liaoning, China.
Department of Endocrinology and Metabolism, Liaoning Provincial Key Laboratory of Endocrine Diseases, the First Hospital of China Medical University, Shenyang 110001, Liaoning, China.
Biomed Environ Sci. 2017 Dec;30(12):932-937. doi: 10.3967/bes2017.126.
Iodine deficiency (ID) during early pregnancy has an adverse effect on children's psychomotor and motor function but the mechanism has not been clarified. Therefore, our aim was to study the effect of maternal marginal ID on cerebellar neurodevelopment and the underlying mechanism. After obtaining marginal ID rats, we examined interactions between Bergmann glia cells (BGs) and Purkinje cells (PCs) using immunofluorescence and expression of the glutamate transporter and receptor by western blot. Our results showed that marginal ID reduced the number of contacted points between BGs and PCs, and disturbed expression of the glutamate transporter and receptor. Our results support the hypothesis that marginal ID inhibits interactions of BGs-PCs, which may be involved in abnormal regulation of the glutamate transporter and receptor.
碘缺乏症（ID）在妊娠早期对儿童的精神运动和运动功能有不良影响，但机制尚未阐明。因此，我们的目的是研究母体边缘性碘缺乏症对小脑神经发育的影响及其潜在机制。在获得边缘性碘缺乏症大鼠后，我们使用免疫荧光法研究了 Bergmann 胶质细胞（BGs）和浦肯野细胞（PCs）之间的相互作用，并通过 Western blot 检测谷氨酸转运体和受体的表达。结果表明，边缘性碘缺乏症减少了 BGs 和 PCs 之间的接触点数量，扰乱了谷氨酸转运体和受体的表达。我们的结果支持这样一种假设，即边缘性碘缺乏症抑制了 BGs-PCs 的相互作用，这可能涉及到谷氨酸转运体和受体的异常调节。
