Weber D J, Rutala W A, Samsa G P, Santimaw J E, Lemon S M
JAMA. 1985 Dec 13;254(22):3187-9.
Factors associated with lack of antibody response to the hepatitis B virus plasma vaccine were retrospectively evaluated by means of a logistic regression in 194 previously seronegative staff members of a community hospital. All subjects had received three doses of vaccine by intramuscular buttock injection using a 1-in, 23-gauge needle. Overall, only 55.7% of subjects developed detectable antibody to hepatitis B surface antigen in serum after immunization. The weight-height index served as a surrogate measure of obesity. Predictors of poor immunogenic response to hepatitis B vaccine included higher weight-height index, older age, and vaccine batch. Sex, race, timing of vaccine doses, and timing of postimmunization determination of antibody to hepatitis B surface antigen were not predictors of vaccine efficacy.
通过对一家社区医院194名既往血清学阴性的工作人员进行逻辑回归分析，回顾性评估了与乙肝病毒血浆疫苗抗体反应缺乏相关的因素。所有受试者均使用1英寸23号针头通过臀部肌肉注射接种了三剂疫苗。总体而言，只有55.7%的受试者在免疫后血清中产生了可检测到的乙肝表面抗原抗体。体重身高指数作为肥胖的替代指标。乙肝疫苗免疫原性反应不佳的预测因素包括较高的体重身高指数、年龄较大和疫苗批次。性别、种族、疫苗接种时间以及免疫后乙肝表面抗原抗体检测时间不是疫苗效力的预测因素。
