即时检测尿液乙基葡糖苷酸检测在赞比亚 HIV-乙型肝炎病毒合并感染成年人中的酒精使用情况。
Point-of-Care Urine Ethyl Glucuronide Testing to Detect Alcohol Use Among HIV-Hepatitis B Virus Coinfected Adults in Zambia.
机构信息
Centre for Infectious Disease Research in Zambia, 5032 Great North Road, PO Box 34681, Lusaka, Zambia.
Department of Medicine, University of Alabama at Birmingham, Birmingham, USA.
出版信息
AIDS Behav. 2018 Jul;22(7):2334-2339. doi: 10.1007/s10461-018-2030-8.
Abstract
In an HIV-hepatitis B virus (HIV-HBV) coinfection cohort in Zambia, we piloted a qualitative point-of-care (POC) test for urine Ethyl glucuronide (uEtG), assessed concordance between uEtG and alcohol use disorders identification test-consumption (AUDIT-C), and identified epidemiological factors associated with underreporting (defined as uEtG-positivity with last reported drink > 7 days prior). Among 211 participants (40.8% women), there were 44 (20.8%) lifetime abstainers, 32 (15.2%) former drinkers, and 135 (64.0%) current drinkers, including 106 (50.2%) with unhealthy drinking per AUDIT-C. Eighty-seven (41.2%) were uEtG-positive including 64 of 65 (98.5%) who drank ≤ 3 days prior and 17 of 134 (12.7%) underreported, all of whom admitted to recent drinking when results were discussed. uEtG was moderately concordant with AUDIT-C. Past drinking (versus lifetime abstinence) and longer time on antiretrovirals (≥ 12 months) were associated with underreporting. These data support further use of POC alcohol biomarkers in HIV and hepatitis research and clinical settings.
摘要
在赞比亚的 HIV-乙型肝炎病毒 (HIV-HBV) 合并感染队列中，我们试点了一种即时尿液乙基葡萄糖醛酸苷 (uEtG) 的定性检测方法，评估了 uEtG 与酒精使用障碍识别测试-消费 (AUDIT-C) 的一致性，并确定了与漏报相关的流行病学因素（定义为 uEtG 阳性且最后一次报告饮酒时间在 7 天之前）。在 211 名参与者（40.8%为女性）中，有 44 名（20.8%）终生戒酒者、32 名（15.2%）曾经饮酒者和 135 名（64.0%）现在饮酒者，包括 106 名（50.2%）根据 AUDIT-C 诊断为不健康饮酒者。87 名（41.2%）uEtG 阳性，其中 64 名（98.5%）在过去 3 天内饮酒，17 名（12.7%）漏报，所有漏报者在讨论结果时都承认最近有饮酒。uEtG 与 AUDIT-C 中度一致。过去饮酒（与终生戒酒相比）和更长时间服用抗逆转录病毒药物（≥12 个月）与漏报相关。这些数据支持在 HIV 和肝炎研究和临床环境中进一步使用即时酒精生物标志物。
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