Herrera-Goepfert Roberto
1 Instituto Nacional de Cancerología, México City, México.
Int J Surg Pathol. 2018 Aug;26(5):469-474. doi: 10.1177/1066896917752863. Epub 2018 Jan 16.
Synovial sarcoma is a ubiquitous neoplasm predominantly affecting soft tissues of young adults of any gender; few cases have been described in the digestive system, mostly in the stomach. The (X;18)(p11.2; q11.2) translocation yields unique SS18-SSX fusion genes. Synovial sarcoma has been related to radiotherapy, but no synovial sarcoma has been associated with the digestive system. This article describes the case of a synovial sarcoma arising along the extrahepatic biliary tree, 10 years after the application of an abdominal radiotherapy schedule due to a retroperitoneal metastatic seminoma in a male who developed progressive obstructive jaundice. Ninety percent of the analyzed cells carried the SS18 gene with separation of sequences, thus denoting a translocation. There are only 8 post-radiotherapy synovial sarcomas that have been reported previously, and this is the first report of a radiotherapy-related synovial sarcoma arising from the extrahepatic biliary tree, and the second case described in this anatomic region.
滑膜肉瘤是一种常见的肿瘤，主要影响任何性别的年轻成年人的软组织；消化系统中仅有少数病例报道，主要位于胃部。（X；18）（p11.2；q11.2）易位产生独特的SS18-SSX融合基因。滑膜肉瘤与放射治疗有关，但尚无与消化系统相关的滑膜肉瘤报道。本文描述了一例沿肝外胆管发生的滑膜肉瘤病例，该男性因腹膜后转移性精原细胞瘤接受腹部放疗计划10年后出现进行性梗阻性黄疸。90%的分析细胞携带SS18基因且序列分离，表明存在易位。此前仅报道过8例放疗后滑膜肉瘤，这是首例源于肝外胆管的放疗相关滑膜肉瘤报道，也是该解剖区域描述的第二例病例。
