Department of Bone and Joint Surgery, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China.
Department of Bone and Joint, Beijing University of Chinese Medicine, Beijing 100029, China.
Chin Med J (Engl). 2018 Jan 20;131(2):194-199. doi: 10.4103/0366-6999.222321.
The quality of the lateral compartment cartilage is important to preoperative evaluation and prognostic prediction of unicompartmental knee arthroplasty (UKA). Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) enables noninvasive assessment of glycosaminoglycan (GAG) content in cartilage. This study aimed to determine the GAG content of the lateral compartment cartilage in knees scheduled to undergo Oxford medial UKA.
From December 2016 to May 2017, twenty patients (20 osteoarthritic knees) conforming to the indications for Oxford medial UKA were included as the osteoarthritis (OA) group, and 20 healthy volunteers (20 knees) paired by sex, knee side, age (±3 years), and body mass index (BMI) (±3 kg/m2) were included as the control group. The GAG contents of the weight-bearing femoral cartilage (wbFC), the posterior non-weight-bearing femoral cartilage (pFC), the lateral femoral cartilage (FC), and tibial cartilage (TC) were detected using dGEMRIC. The dGEMRIC indices (T1Gd) were calculated in the middle three consecutive slices of the lateral compartment. Paired t-tests were used to compare the T1Gd in each region of interest between the OA group and control group.
The average age and BMI in the two groups were similar. In the OA group, T1Gd of FC and TC was 386.7 ± 50.7 ms and 429.6 ± 59.9 ms, respectively. In the control group, T1Gd of FC and TC was 397.5 ± 52.3 ms and 448.6 ± 62.5 ms, respectively. The respective T1Gd of wbFC and pFC was 380.0 ± 47.8 ms and 391.0 ± 66.3 ms in the OA group and 400.3 ± 51.5 ms and 393.6 ± 57.9 ms in the control group. Although the T1Gd of wbFC and TC tended to be lower in the OA group than the control group, there was no significant difference between groups in the T1Gd in any of the analyzed cartilage regions (P value of wbFC, pFC, FC, and TC was 0.236, 0.857, 0.465, and 0.324, respectively).
The GAG content of the lateral compartment cartilage in knees conforming to indications for Oxford medial UKA is similar with those of age- and BMI-matched participants without OA.
外侧间室软骨的质量对于单髁膝关节置换术（UKA）的术前评估和预后预测很重要。软骨延迟钆增强磁共振成像（dGEMRIC）可实现对软骨中糖胺聚糖（GAG）含量的无创评估。本研究旨在确定拟行牛津内侧 UKA 的膝关节外侧间室软骨的 GAG 含量。
2016 年 12 月至 2017 年 5 月，纳入符合牛津内侧 UKA 适应证的 20 例（20 例膝关节骨关节炎）患者作为骨关节炎（OA）组，另纳入 20 名性别、膝关节侧别、年龄（±3 岁）和体质量指数（BMI）（±3kg/m2）相匹配的健康志愿者作为对照组。采用 dGEMRIC 检测负重股骨软骨（wbFC）、非负重后股骨软骨（pFC）、外侧股骨软骨（FC）和胫骨软骨（TC）的 GAG 含量。计算外侧间室中连续三个中间切片的 dGEMRIC 指数（T1Gd）。采用配对 t 检验比较 OA 组和对照组各感兴趣区的 T1Gd。
两组的平均年龄和 BMI 相似。在 OA 组中，FC 和 TC 的 T1Gd 分别为 386.7±50.7ms 和 429.6±59.9ms。在对照组中，FC 和 TC 的 T1Gd 分别为 397.5±52.3ms 和 448.6±62.5ms。OA 组的 wbFC 和 pFC 的 T1Gd 分别为 380.0±47.8ms 和 391.0±66.3ms，对照组分别为 400.3±51.5ms 和 393.6±57.9ms。虽然 OA 组 wbFC 和 TC 的 T1Gd 倾向于低于对照组，但各组分析的软骨区域的 T1Gd 无显著差异（wbFC、pFC、FC 和 TC 的 P 值分别为 0.236、0.857、0.465 和 0.324）。
符合牛津内侧 UKA 适应证的膝关节外侧间室软骨的 GAG 含量与无骨关节炎的年龄和 BMI 匹配参与者相似。
