Yang Jianguo, Mo Hanjie, Wu Haijian, Cao Dongdong, Pan Chengmin, Wang Zhiming
School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou, Zhejiang 317000, P. R. China.
Chem Commun (Camb). 2018 Jan 31;54(10):1213-1216. doi: 10.1039/c7cc07435b.
A highly regio- and stereoselective Pd-catalyzed cascade reaction of allenoate adducts has been developed. Various allenoate adducts of phosphine-catalyzed addition of allenoates are found to be efficient substrates for the preparation of 2,3-dihydrobenzofuran. It is the first example of allenoate adducts used as ideal and practical precursors of hard-to-get functionalized 1,3-butadienes for heterocycle synthesis.
已开发出一种高度区域和立体选择性的钯催化联烯酸酯加合物的串联反应。发现膦催化联烯酸酯加成反应得到的各种联烯酸酯加合物是制备2,3-二氢苯并呋喃的有效底物。这是联烯酸酯加合物用作难以获得的官能化1,3-丁二烯用于杂环合成的理想且实用前体的首个实例。
