Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway; K.G. Jebsen Center for Cardiac Research, University of Oslo and Center for Heart Failure Research, Oslo University Hospital, Oslo, Norway.
Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Oslo, Norway; K.G. Jebsen Center for Cardiac Research, University of Oslo and Center for Heart Failure Research, Oslo University Hospital, Oslo, Norway; Department of Bioengineering, University of California San Diego, La Jolla, CA, United States.
Matrix Biol. 2019 Jan;75-76:286-299. doi: 10.1016/j.matbio.2018.01.001. Epub 2018 Jan 12.
Extracellular matrix remodeling is extensive in several heart diseases and hampers cardiac filling, often leading to heart failure. Proteoglycans have over the last two decades emerged as molecules with important roles in matrix remodeling and fibrosis in the heart. Here we discuss and review current literature on proteoglycans that have been studied in cardiac remodeling. The small leucine rich proteoglycans (SLRPs) are located within the extracellular matrix and are organizers of the matrix structure. Membrane-bound proteoglycans, such as syndecans and glypicans, act as receptors and direct cardiac fibroblast signaling. Recent studies indicate that proteoglycans are promising as diagnostic biomarkers for cardiac fibrosis, and that they may provide new therapeutic strategies for cardiac disease.
细胞外基质重塑在多种心脏疾病中广泛存在，并阻碍心脏充盈，常导致心力衰竭。在过去的二十年中，蛋白聚糖已成为心脏基质重塑和纤维化中具有重要作用的分子。在这里，我们讨论和综述了目前关于在心脏重构中研究的蛋白聚糖的文献。小富含亮氨酸的蛋白聚糖（SLRPs）位于细胞外基质内，是基质结构的组织者。膜结合蛋白聚糖，如 syndecans 和 glypicans，作为受体并直接调节心脏成纤维细胞信号。最近的研究表明，蛋白聚糖有望成为心脏纤维化的诊断生物标志物，并且它们可能为心脏疾病提供新的治疗策略。
