Wang Yan, Costanza Frankie, Li Chunpu, Nimmagadda Alekhya, Song Daqian, Cai Jianfeng
J Biomed Nanotechnol. 2016 Jul;12(7):1510-19. doi: 10.1166/jbn.2016.2253.
One of the biggest challenges in developing microRNA (miRNA) based therapeutics is the method of delivery. Herein we report the design and synthesis of mPEG-poly(amino acid)s, which we used as a novel nanocarrier for the delivery of miRNA-139-5p. The PEG-poly(amino acid)s/miRNA-139-5p nanoparticle complex is more effective at suppressing tumor growth and migration in mice with colorectal cancer than when treated with miRNA-139-5p solution and blank nanoparticles individually. Our results suggest that PEG-poly(amino acid)s are a promising non-viral gene vector for the delivery of miRNAs to treat cancers.
开发基于微小RNA（miRNA）的疗法面临的最大挑战之一是递送方法。在此，我们报告了甲氧基聚乙二醇-聚氨基酸（mPEG-聚氨基酸）的设计与合成，我们将其用作递送miRNA-139-5p的新型纳米载体。与单独用miRNA-139-5p溶液和空白纳米颗粒处理相比，聚乙二醇-聚氨基酸/miRNA-139-5p纳米颗粒复合物在抑制结直肠癌小鼠肿瘤生长和迁移方面更有效。我们的结果表明，聚乙二醇-聚氨基酸是一种有前景的非病毒基因载体，可用于递送miRNA以治疗癌症。
