Brambilla F, Cavagnini F, Invitti C, Poterzio F, Lampertico M, Sali L, Maggioni M, Candolfi C, Panerai A E, Müller E E
Psychiatry Res. 1985 Oct;16(2):165-76. doi: 10.1016/0165-1781(85)90010-1.
Clinical and biochemical data suggest a link between anorexia nervosa (AN) and primary affective disorders (PAD). In 14 female patients, aged 15-40 years, with 7-month to 11-year histories of AN, we studied circadian cortisol periodicity, response to the dexamethasone suppression test (DST), and plasma levels of beta-endorphin and beta-lipotropin before and after desimipramine therapy. Possible correlations were sought among neuroendocrine impairments, weight loss, and depressive symptomatology. Impaired circadian cortisol periodicity, blunted DST response, and increased beta-endorphin plasma levels, observed in a subgroup of patients, could not be related to weight loss, either before or after therapy. Instead, a trend toward a relationship between neuroendocrine impairments and depressive symptoms was observed before and after treatment.
临床和生化数据表明神经性厌食症（AN）与原发性情感障碍（PAD）之间存在联系。在14名年龄在15至40岁之间、患有7个月至11年神经性厌食症病史的女性患者中，我们研究了地塞米松抑制试验（DST）前、后的昼夜皮质醇周期性、对该试验的反应以及β-内啡肽和β-促脂素的血浆水平。我们探寻了神经内分泌损伤、体重减轻和抑郁症状之间可能存在的相关性。在部分患者中观察到的昼夜皮质醇周期性受损、DST反应迟钝以及β-内啡肽血浆水平升高，在治疗前后均与体重减轻无关。相反，在治疗前后均观察到神经内分泌损伤与抑郁症状之间存在一种关联趋势。
