Genazzani A R, Petraglia F, Facchinetti F, Monittola C, Scarone S, Brambilla F
Neuropsychobiology. 1984;12(2-3):78-85. doi: 10.1159/000118114.
Mean plasma levels of beta-endorphin (beta EP), beta-lipotropin (beta LPH) and ACTH were significantly higher in 22 patients with primary affective disorders (PAD) and in 2 schizoaffective subjects off therapy since 10 days than in 22 age- and sex-matched healthy controls. Desimipramine therapy (50-100 mg/day per os for 3-5 weeks) induced in parallel psychological improvement and fall in beta LPH-beta EP in 6 of 8 PAD patients treated, and a normalization of beta EP-beta LPH levels with minimal mood improvement in the 2 schizoaffective subjects. These results indicate that the opioid levels are increased in PAD and schizoaffective patients and normalized by the desimipramine therapy in those patients in whom the affective disorders improved.
22例原发性情感障碍（PAD）患者和2例已停药10天的分裂情感性障碍患者的血浆β-内啡肽（β-EP）、β-促脂素（β-LPH）和促肾上腺皮质激素（ACTH）平均水平显著高于22名年龄和性别匹配的健康对照者。在接受治疗的8例PAD患者中，有6例接受去甲丙咪嗪治疗（口服50-100mg/天，持续3-5周）后，心理状况得到改善，同时β-LPH-β-EP水平下降；2例分裂情感性障碍患者的β-EP-β-LPH水平恢复正常，但情绪改善不明显。这些结果表明，PAD和分裂情感性障碍患者的阿片样物质水平升高，而去甲丙咪嗪治疗可使情感障碍得到改善的患者的阿片样物质水平恢复正常。
